Once-Nightly Sodium Oxybate (FT218) Demonstrated Improvement of Symptoms in a Phase 3 Randomized Clinical Trial in Patients With Narcolepsy.
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DOI: 10.1093/sleep/zsab200
Abstract: STUDY OBJECTIVES To assess the efficacy and safety of FT218, a novel once-nightly formulation of sodium oxybate (ON-SXB), in patients with narcolepsy in the phase 3 REST-ON trial. METHODS Narcolepsy patients aged ≥16 years were… read more here.
Keywords: improvement; sxb; ft218; sodium oxybate ... See more keywords
0579 Long-Term Safety of Once-Nightly Oxybate for Narcolepsy: RESTORE Study Interim Analysis of Data
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DOI: 10.1093/sleep/zsad077.0579
Abstract: The pivotal phase 3 REST-ON trial (NCT02720744) evaluated the efficacy and safety of once-nightly sodium oxybate (ON-SXB; FT218), an investigational extended-release formulation for treatment of adults with narcolepsy. In REST-ON, ON-SXB met its 3 coprimary… read more here.
Keywords: safety; oxybate; sxb; restore study ... See more keywords
Sodium Oxybate in Treatment-Resistant REM Sleep Behavior Disorder.
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DOI: 10.1093/sleep/zsad103
Abstract: STUDY OBJECTIVES Symptomatic therapies for REM sleep behavior disorder (RBD) are limited. Sodium oxybate (SXB), a gamma-aminobutyric acid (GABA)-B agonist, could be effective but has not been evaluated against placebo. METHODS This double-blind, parallel-group, randomized,… read more here.
Keywords: sleep behavior; rbd; behavior disorder; rem sleep ... See more keywords
Effects of sodium oxybate on hypocretin/orexin and locus coeruleus neurons.
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DOI: 10.1093/sleep/zsad135
Abstract: Longterm use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate (GHB)) attenuates the cataplexy and sleepiness of human narcolepsy. We had previously found that chronic opiate usage in humans and longterm opiate administration to mice significantly… read more here.
Keywords: sodium oxybate; hypocretin orexin; locus coeruleus; sxb ... See more keywords