A possible mechanism of inhibition of U87MG and SH-SY5Y cancer cell proliferation by diallyl trisulfide and other aspects of its activity
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2484-4
Abstract: The study was conducted to elucidate the mechanism of antiproliferative and antioxidative action of diallyl trisulfide (DATS), a garlic-derived organosulfur compound. Changes in the l-cysteine desulfuration, and the levels of cystathionine and non-protein thiols in… read more here.
Keywords: diallyl trisulfide; diallyl; mechanism; inhibition ... See more keywords
Effect of M2 Macrophage-Derived Soluble Factors on Proliferation and Apoptosis of SH-SY5Y Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05169-5
Abstract: Macrophages play the key role in the regulation of neuroregeneration. For evaluation of the neuroregenerative potential of M2 macrophages, we studied the effect of macrophages polarized with IL-4 (M2a (IL-4)) and by efferocytosis under conditions… read more here.
Keywords: effect; sy5y; apoptosis sy5y; soluble factors ... See more keywords
The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00956-6
Abstract: Recent studies have shown that proton pump inhibitors have positive effects on the nervous system. However, its effect on epileptic seizure and neuronal damage are still unclear. In this study, it was aimed to investigate… read more here.
Keywords: pump inhibitors; pantoprazole pentylenetetrazole; sy5y; proton pump ... See more keywords
The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic brain disease"
DOI: 10.1007/s11011-022-00990-x
Abstract: Sulforaphane (SFN) promotes protective effects in different cell types. Nonetheless, it remains to be clarified by which mechanism SFN exerts benefits in mammalian cells. Mitochondria are a major source of adenosine triphosphate (ATP) and reactive… read more here.
Keywords: sfn; bv2 cells; mitochondrial impairment; heme oxygenase ... See more keywords
Glycyrrhizic Acid Alleviates 6-Hydroxydopamine and Corticosterone-Induced Neurotoxicity in SH-SY5Y Cells Through Modulating Autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2609-5
Abstract: Recent researches have shown that autophagy is associated with the pathogenesis of neurodegenerative disorders, but there is no paper to investigate the effects of autophagy modulation on Parkinson’s disease depression (PDD). In addition, glycyrrhizic acid… read more here.
Keywords: corticosterone; neurotoxicity sy5y; sy5y; glycyrrhizic acid ... See more keywords
Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical Research"
DOI: 10.1007/s11064-021-03504-w
Abstract: Curcumin is a natural polyphenolic compound with neuroprotective and antioxidant properties. Acrylamide (ACR) is a by-product of food processing that produces neurotoxicity in humans and animals. The pancreatic endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)… read more here.
Keywords: eif2 signaling; sy5y; induced neurotoxicity; acr induced ... See more keywords
Neuroprotective effect of FMS-like tyrosine kinase-3 silence on cerebral ischemia/reperfusion injury in a SH-SY5Y cell line.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.01.043
Abstract: Neuron damage contributes to ischemic brain injury. Although FMS-like tyrosine kinase-3 (FLT3) plays a critical role in neuron survival, its function and molecular mechanism in cerebral ischemia/reperfusion injury is unclear. In the present study, we… read more here.
Keywords: sy5y cell; silence; sy5y; ischemia reperfusion ... See more keywords
Temporal Proteomic Profiling of SH-SY5Y Differentiation with Retinoic Acid Using FAIMS and Real-Time Searching.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.0c00614
Abstract: The SH-SY5Y cell line is often used as a surrogate for neurons in cell-based studies. This cell line is frequently differentiated with all-trans retinoic acid (ATRA) over a 7-day period, which confers neuron-like properties to… read more here.
Keywords: real time; acid using; sy5y; retinoic acid ... See more keywords
Apoptotic-induced Effects of Castanea sativa Bark Extract in Human SH-SY5Y Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Communications"
DOI: 10.1177/1934578x1801300726
Abstract: Castanea sativa Mill. wood extract (ENC) has health-promoting qualities such as antibacterial, antiviral, antispasmodic, cardio- and neuroprotective-activities. Its potential towards cancer cells of the central nervous system, however, is still unexplored. This study investigates the… read more here.
Keywords: apoptotic induced; castanea sativa; neuroblastoma; induced effects ... See more keywords
The SH-SY5Y cell line in Parkinson’s disease research: a systematic review
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0149-0
Abstract: Parkinson’s disease (PD) is a devastating and highly prevalent neurodegenerative disease for which only symptomatic treatment is available. In order to develop a truly effective disease-modifying therapy, improvement of our current understanding of the molecular… read more here.
Keywords: research; cell line; disease; sy5y ... See more keywords
Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-017-0151-8
Abstract: BackgroundExposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional studies on animals.… read more here.
Keywords: induced neurotoxicity; p19 neurons; toxicity; sy5y ... See more keywords