Cycloadditions of anionic N-heterocyclic carbenes of sydnone imines
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.04.006
Abstract: Abstract Sydnone imines were deprotonated with lithium bis(trimethylsilyl)amide at the C4 position to give the corresponding sydnone imine anions as lithium adducts. These can be represented as lithium stabilized anionic N-heterocyclic carbenes. Treatment with diisopropyl… read more here.
Keywords: heterocyclic carbenes; sydnone imine; anionic heterocyclic; cycloadditions anionic ... See more keywords
Origins of halogen effects in bioorthogonal sydnone cycloadditions.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc02128g
Abstract: Halogen substituents increase sydnone cycloaddition reactivities substantially. Fluoro-sydnones are superior to bromo- and chloro-sydnones, and can achieve extremely high second-order rate constants with strained alkynes. Computational studies have revealed the fluorine substituent increases the reactivity… read more here.
Keywords: sydnone cycloadditions; effects bioorthogonal; origins halogen; bioorthogonal sydnone ... See more keywords
Regioselective synthesis of 3-trifluoromethyl 1,2,4-triazoles via photocycloaddition of sydnone with CF3CN.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03928a
Abstract: A general and regioselective synthesis of 3-trifluoromethyl 1,2,4-triazoles has been achieved through photocycloaddition of sydnone with trifluoroacetonitrile. This method employed trifluoroacetaldehyde O-(aryl)oxime as the CF3CN precursor and tolerated various functional groups to furnish 3-trifluoromethyl 1,2,4-triazole… read more here.
Keywords: synthesis trifluoromethyl; trifluoromethyl triazoles; photocycloaddition sydnone; regioselective synthesis ... See more keywords
Antiproliferative, apoptosis-inducing activity and molecular docking studies of sydnones compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cancer research and therapeutics"
DOI: 10.4103/jcrt.jcrt_1614_20
Abstract: Objective To evaluate the antiproliferative and apoptosis inducing activity of different sydnones on cancer cell lines and their interaction with cancer proteins by molecular docking studies. Material and Methods Antiproliferative activity was carried out by… read more here.
Keywords: molecular docking; cancer; activity; sydnone ... See more keywords