d-dimensional SYK, AdS loops, and 6j symbols
Sign Up to like & getrecommendations! Published in 2019 at "Journal of High Energy Physics"
DOI: 10.1007/jhep03(2019)052
Abstract: A bstractWe study the 6j symbol for the conformal group, and its appearance in three seemingly unrelated contexts: the SYK model, conformal representation theory, and perturbative amplitudes in AdS. The contribution of the planar Feynman… read more here.
Keywords: loops symbols; ads loops; dimensional syk; symbol ... See more keywords
The role of Syk in peripheral T cells.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2018.04.007
Abstract: The aim of this study was to understand how Syk affects peripheral T cell function. T cells from Syk-/- chimeric mice and DR1 Sykfl/fl CD4cre conditional mice gave strong CD3-induced Th1, Th2, and Th17 cytokine… read more here.
Keywords: peripheral cells; syk peripheral; role syk; syk ... See more keywords
Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134992
Abstract: The Spleen Tyrosine Kinase (SYK) is known for its involvement in B-cell and T-cell signaling, modulating the peripheral immune response. We have previously shown that SYK is overactive in the brains of human Alzheimer's Disease… read more here.
Keywords: p301s mice; tau p301s; pathology; syk ... See more keywords
The Syk kinases orchestrate cerebellar granule cell tangential migration
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.07.057
Abstract: The tyrosine kinases of the Syk family are essential components of the well-characterized immunoreceptor ITAM-based signaling pathway. However, ITAM-based signaling typically does not function in isolation. Instead, it is enmeshed in the molecular network controlling… read more here.
Keywords: migration syk; syk kinases; tangential migration; syk ... See more keywords
SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
Sign Up to like & getrecommendations! Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-0277-6
Abstract: Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 triggered pro-survival pathways may contribute to primary drug… read more here.
Keywords: pro survival; mutated myd88; syk; myd88 mutated ... See more keywords
Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib.
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2131751
Abstract: Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target… read more here.
Keywords: kinase syk; biology; tyrosine kinase; spleen tyrosine ... See more keywords
P6493Syk activation is a defense mechanism in murine model of aortic dissection
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.1083
Abstract: Aortic dissection (AD) is a serious clinical condition with unknown etiology that frequently results in fatal outcome. Recent studies showed essential role of inflammatory response both in promoting AD and aortic aneurysm (AA). However, the… read more here.
Keywords: group; aortic dissection; syk; model ... See more keywords
The role of Syk/IĸB‐α/NF‐ĸB pathway activation in the reversal effect of BAY 61‐3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan‐induced non‐septic shock
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12864
Abstract: Spleen tyrosine kinase (Syk), a non‐receptor tyrosine kinase, plays an important role in allergic diseases and inflammation. Syk triggers several intracellular signalling cascades including Toll‐like receptor signalling to activate inflammatory responses following fungal infection but… read more here.
Keywords: inflammation; syk; induced non; hypotension inflammation ... See more keywords
Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15964
Abstract: Thrombosis is a major cause of morbidity and mortality worldwide. Platelet activation by exposed collagen through glycoprotein VI (GPVI) and formation of neutrophil extracellular traps (NETs) are critical pathogenic factors for arterial and venous thrombosis.… read more here.
Keywords: asebogenin suppresses; formation via; suppresses thrombus; thrombus formation ... See more keywords
Tumor cell SYK expression modulates the tumor immune microenvironment composition in human cancer via TNF-α dependent signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005113
Abstract: Background The expression of SYK in cancer cells has been associated with both tumor promoting and tumor suppressive effects. Despite being proposed as anticancer therapeutic target, the possible role of SYK in modulating local adaptive… read more here.
Keywords: syk; expression; tumor cell; tumor ... See more keywords
Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma
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DOI: 10.1158/1078-0432.ccr-16-2185
Abstract: Purpose: Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TK) and associated pathways are continuously activated in many malignancies, including EWS; these enzymes provide candidate therapeutic targets. Experimental… read more here.
Keywords: ews cells; syk myc; malat1; syk ... See more keywords