Wormhole-induced effective coupling in SYK chains
Sign Up to like & getrecommendations! Published in 2024 at "Journal of High Energy Physics"
DOI: 10.1007/jhep02(2025)142
Abstract: Inhomogeneous quantum chains have recently been considered in the context of developing novel discrete realizations of holographic dualities. To advance this programme, we explore the ground states of infinite chains with large number N of… read more here.
Keywords: coupling syk; syk chains; induced effective; wormhole induced ... See more keywords
d-dimensional SYK, AdS loops, and 6j symbols
Sign Up to like & getrecommendations! Published in 2019 at "Journal of High Energy Physics"
DOI: 10.1007/jhep03(2019)052
Abstract: A bstractWe study the 6j symbol for the conformal group, and its appearance in three seemingly unrelated contexts: the SYK model, conformal representation theory, and perturbative amplitudes in AdS. The contribution of the planar Feynman… read more here.
Keywords: loops symbols; ads loops; dimensional syk; symbol ... See more keywords
The role of Syk in peripheral T cells.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2018.04.007
Abstract: The aim of this study was to understand how Syk affects peripheral T cell function. T cells from Syk-/- chimeric mice and DR1 Sykfl/fl CD4cre conditional mice gave strong CD3-induced Th1, Th2, and Th17 cytokine… read more here.
Keywords: peripheral cells; syk peripheral; role syk; syk ... See more keywords
Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134992
Abstract: The Spleen Tyrosine Kinase (SYK) is known for its involvement in B-cell and T-cell signaling, modulating the peripheral immune response. We have previously shown that SYK is overactive in the brains of human Alzheimer's Disease… read more here.
Keywords: p301s mice; tau p301s; pathology; syk ... See more keywords
The Syk kinases orchestrate cerebellar granule cell tangential migration
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.07.057
Abstract: The tyrosine kinases of the Syk family are essential components of the well-characterized immunoreceptor ITAM-based signaling pathway. However, ITAM-based signaling typically does not function in isolation. Instead, it is enmeshed in the molecular network controlling… read more here.
Keywords: migration syk; syk kinases; tangential migration; syk ... See more keywords
SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
Sign Up to like & getrecommendations! Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-0277-6
Abstract: Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 triggered pro-survival pathways may contribute to primary drug… read more here.
Keywords: pro survival; mutated myd88; syk; myd88 mutated ... See more keywords
ANGPTL4 promoted the cognitive impairment in vascular dementia via increasing integrin/p-Syk signalings induced mitochondrial autophagy and apoptosis in the hippocampus
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07811-y
Abstract: The aim of this study was to investigate the effects and mechanisms of ANGPTL4 on cognitive impairment in vascular dementia rats. 36 SD rats were randomly divided into Sham(n= 9), VaD(n= 9), VaD + ANGPTL4 OE(n= 9), and VaD + ANGPTL4 KD(n= 9).… read more here.
Keywords: vascular dementia; cognitive impairment; syk; angptl4 ... See more keywords
Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib.
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2131751
Abstract: Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target… read more here.
Keywords: kinase syk; biology; tyrosine kinase; spleen tyrosine ... See more keywords
Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets
Sign Up to like & getrecommendations! Published in 2024 at "Platelets"
DOI: 10.1080/09537104.2024.2369766
Abstract: Abstract Receptor-induced tyrosine phosphorylation of spleen tyrosine kinase (Syk) has been studied extensively in hematopoietic cells. Metabolic mapping and high-resolution mass spectrometry, however, indicate that one of the most frequently detected phosphorylation sites encompassed S297… read more here.
Keywords: phosphorylation; function; activation; syk ... See more keywords
P6493Syk activation is a defense mechanism in murine model of aortic dissection
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.1083
Abstract: Aortic dissection (AD) is a serious clinical condition with unknown etiology that frequently results in fatal outcome. Recent studies showed essential role of inflammatory response both in promoting AD and aortic aneurysm (AA). However, the… read more here.
Keywords: group; aortic dissection; syk; model ... See more keywords
Sparsity dependence of Krylov state complexity in the SYK model
Sign Up to like & getrecommendations! Published in 2024 at "Physical Review D"
DOI: 10.1103/qsyk-m3sg
Abstract: We study the Krylov state complexity of the Sachdev-Ye-Kitaev (SYK) model for N≤28 Majorana fermions with q-body fermion interaction with q=4, 6, 8 for a range of sparse parameter k that controls the number of… read more here.
Keywords: krylov state; state complexity; complexity; syk model ... See more keywords