SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy008
Abstract: Background Glioblastoma (GBM) is one of the most aggressive human brain tumors, with a median survival of 15-18 months. There is a desperate need to find novel therapeutic targets. Various receptor protein kinases have been… read more here.
Keywords: proliferation migration; glioma; syk inhibition; tumor microenvironment ... See more keywords
Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade8272
Abstract: Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19). Fostamatinib, a SYK inhibitor, was studied in a phase 2 placebo-controlled randomized clinical trial… read more here.
Keywords: inhibition; syk inhibition; covid; tyrosine kinase ... See more keywords
Syk inhibitors protect against microglia-mediated neuronal loss in culture
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1120952
Abstract: Microglia are brain macrophages and play beneficial and/or detrimental roles in many brain pathologies because of their inflammatory and phagocytic activity. Microglial inflammation and phagocytosis are thought to be regulated by spleen tyrosine kinase (Syk),… read more here.
Keywords: syk inhibitors; syk inhibition; syk; neuronal loss ... See more keywords
SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells In Vitro
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DOI: 10.3390/cancers11020202
Abstract: Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity… read more here.
Keywords: syk; syk inhibition; chemotherapeutic drugs; effect ... See more keywords
Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach
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DOI: 10.3390/cancers14194691
Abstract: Simple Summary B-cell lymphomas represent the majority of non-Hodgkin lymphomas and are the most common lymphoid malignancies in the Western world. Genetic alterations or epigenetic modulations can lead to tumor initiation and tumor progression. Aside… read more here.
Keywords: cell; syk inhibition; inhibition; bet syk ... See more keywords