Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib.
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2131751
Abstract: Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target… read more here.
Keywords: kinase syk; biology; tyrosine kinase; spleen tyrosine ... See more keywords
THU0042 EFFECT OF SPLEEN TYROSIN KINASE (SYK)-INHIBITORS ON RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS
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DOI: 10.1136/annrheumdis-2019-eular.4865
Abstract: Background: The spleen tyrosine kinase (syk) is an intracellular protein kinase involved in signal transmission processes of immune cells and non-hematopoietic cells, such as fibroblasts. Various syk-inhibitors are therefore currently being tested in preclinical and… read more here.
Keywords: tak 659; kinase; rasf; effect ... See more keywords
Syk inhibitors protect against microglia-mediated neuronal loss in culture
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DOI: 10.3389/fnagi.2023.1120952
Abstract: Microglia are brain macrophages and play beneficial and/or detrimental roles in many brain pathologies because of their inflammatory and phagocytic activity. Microglial inflammation and phagocytosis are thought to be regulated by spleen tyrosine kinase (Syk),… read more here.
Keywords: syk inhibitors; syk inhibition; syk; neuronal loss ... See more keywords