The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations
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DOI: 10.1111/jcmm.14820
Abstract: Mutations in the E3 ubiquitin ligase CBL, found in several myeloid neoplasms, lead to decreased ubiquitin ligase activity. In murine systems, these mutations are associated with cytokine‐independent proliferation, thought to result from the activation of… read more here.
Keywords: mutant cbl; leukaemia cells; kinase; inhibition ... See more keywords