MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00688-2
Abstract: Neuronal connectivity is dependent on size and shape of the dendritic arbor. However, mechanisms controlling dendritic arborization, especially in the peripheral nervous system, are not completely understood. Previous studies have shown that bone morphogenetic proteins… read more here.
Keywords: sympathetic neurons; dendritic growth; bmp induced; growth ... See more keywords
Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0173
Abstract: Human induced pluripotent stem cells (hiPSC) offer an unprecedented opportunity to generate model systems that facilitate a mechanistic understanding of human disease. Current differentiation protocols are capable of generating cardiac myocytes (hiPSC-CM) and sympathetic neurons… read more here.
Keywords: cell; pluripotent stem; sympathetic neurons; induced pluripotent ... See more keywords
Sympathetic Neurons Regulate Cardiomyocyte Maturation in Culture
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.850645
Abstract: Embryos devoid of autonomic innervation suffer sudden cardiac death. However, whether autonomic neurons have a role in heart development is poorly understood. To investigate if sympathetic neurons impact cardiomyocyte maturation, we co-cultured phenotypically immature cardiomyocytes… read more here.
Keywords: neurons regulate; maturation; maturation culture; regulate cardiomyocyte ... See more keywords
Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.995474
Abstract: The Spontaneously Hypertensive Rat (SHR) has increased sympathetic drive to the periphery that precedes and contributes to the development of high blood pressure, making it a useful model for the study of neurogenic hypertension. Comparisons… read more here.
Keywords: shr neurons; postnatal period; sympathetic neurons; shr ... See more keywords
A Calcium-Dependent Chloride Current Increases Repetitive Firing in Mouse Sympathetic Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00508
Abstract: Ca2+-activated ion channels shape membrane excitability in response to elevations in intracellular Ca2+. The most extensively studied Ca2+-sensitive ion channels are Ca2+-activated K+ channels, whereas the physiological importance of Ca2+-activated Cl- channels has been poorly… read more here.
Keywords: repetitive firing; sympathetic neurons; ca2 activated; mouse sympathetic ... See more keywords
Post-Ganglionic Sympathetic Neurons can Directly Sense Raised Extracellular Na+ via SCN7a/Nax
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.931094
Abstract: The relationship between dietary NaCl intake and high blood pressure is well-established, and occurs primarily through activation of the sympathetic nervous system. Nax, a Na+-sensitive Na+ channel, plays a pivotal role in driving sympathetic excitability,… read more here.
Keywords: post ganglionic; sympathetic neurons; extracellular via; ganglionic sympathetic ... See more keywords
Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911098
Abstract: Doxorubicin (DOXO) remains amongst the most commonly used anti-cancer agents for the treatment of solid tumors, lymphomas, and leukemias. However, its clinical use is hampered by cardiotoxicity, characterized by heart failure and arrhythmias, which may… read more here.
Keywords: effect; cardiac sympathetic; doxorubicin; sympathetic neurons ... See more keywords