Psychological interventions to reduce positive symptoms in schizophrenia: systematic review and network meta‐analysis
Sign Up to like & getrecommendations! Published in 2018 at "World Psychiatry"
DOI: 10.1002/wps.20577
Abstract: Psychological treatments are increasingly regarded as useful interventions for schizophrenia. However, a comprehensive evaluation of the available evidence is lacking and the benefit of psychological interventions for patients with current positive symptoms is still debated.… read more here.
Keywords: network; positive symptoms; symptoms schizophrenia; psychological interventions ... See more keywords
[Transcranial electrical brain stimulation methods for treatment of negative symptoms in schizophrenia].
Sign Up to like & getrecommendations! Published in 2021 at "Der Nervenarzt"
DOI: 10.1007/s00115-021-01065-5
Abstract: In recent years noninvasive brain stimulation (NIBS) applications have emerged as a third and novel treatment option alongside psychopharmacology and psychotherapy in the treatment of mental diseases. It is assumed that NIBS could represent a supplement or… read more here.
Keywords: treatment negative; negative symptoms; treatment; symptoms schizophrenia ... See more keywords
Electroconvulsive therapy for negative symptoms in schizophrenia: a literature review from 2000 to 2021
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DOI: 10.1007/s12144-021-01989-w
Abstract: Negative symptoms in schizophrenia remain a clinical challenge with small effect sizes and evidence for pharmacological or psychotherapeutic treatment approaches. Studies suggest that electroconvulsive therapy (ECT) holds some promise as a treatment option of often… read more here.
Keywords: electroconvulsive therapy; treatment; symptoms schizophrenia; negative symptoms ... See more keywords
The efficacy of cariprazine in negative symptoms of schizophrenia: Post hoc analyses of PANSS individual items and PANSS-derived factors
Sign Up to like & getrecommendations! Published in 2019 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2019.01.015
Abstract: Abstract Background: Negative symptoms in schizophrenia are heterogeneous and multidimensional; effective treatments are lacking. Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, was significantly more effective than risperidone in… read more here.
Keywords: post hoc; negative symptoms; symptoms schizophrenia; panss derived ... See more keywords
Hypoactivity of the lateral habenula contributes to negative symptoms and cognitive dysfunction of schizophrenia in rats
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.05.005
Abstract: Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral… read more here.
Keywords: schizophrenia; negative cognitive; mpfc; symptoms schizophrenia ... See more keywords
Affective symptoms in schizophrenia are strongly associated with neurocognitive deficits indicating disorders in executive functions, visual memory, attention and social cognition
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.06.031
Abstract: The aim of this study was to assess the neurocognitive correlates of affective symptoms in schizophrenia. Towards this end, 40 healthy controls and 80 schizophrenia patients were investigated with six tests of the Cambridge Neuropsychological… read more here.
Keywords: affective symptoms; symptoms schizophrenia; deficits indicating; neurocognitive deficits ... See more keywords
Depressive, anxiety and hypomanic symptoms in schizophrenia may be driven by tryptophan catabolite (TRYCAT) patterning of IgA and IgM responses directed to TRYCATs
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.06.033
Abstract: The aim of this study was to delineate the associations between the tryptophan catabolite (TRYCAT) pathway and affective symptoms in schizophrenia. Towards this end we measured immunoglobulin (Ig)A and IgM responses to relatively noxious TRYCATs,… read more here.
Keywords: negative symptoms; anxiety; anxiety hypomanic; symptoms schizophrenia ... See more keywords
Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task.
Sign Up to like & getrecommendations! Published in 2023 at "Psychological medicine"
DOI: 10.1017/s0033291723000521
Abstract: BACKGROUND A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release… read more here.
Keywords: negative symptoms; rpe; reward; cortex ... See more keywords
SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia
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DOI: 10.1073/pnas.2203711119
Abstract: Significance Selenium-binding protein 1 (SELENBP1) is up-regulated in the prefrontal cortex of patients with schizophrenia as per postmortem reports, including the present study. However, no causative link between SELENBP1 and schizophrenia has yet been established.… read more here.
Keywords: negative symptoms; cortex; selenbp1 overexpression; prefrontal cortex ... See more keywords
T175. THE GUT-MICROBIOTA AS A TARGET FOR THE TREATMENT OF NEGATIVE SYMPTOMS OF SCHIZOPHRENIA: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED TRIALS OF ADD-ON STRATEGIES
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa029.735
Abstract: Abstract Background None of the currently available treatments are effective for negative symptoms of schizophrenia, which represent a long-lasting burden on sufferers, their families and on wider society. The gut-microbiota has been emerging as a… read more here.
Keywords: negative symptoms; treatment; symptoms schizophrenia; gut microbiome ... See more keywords
Placebo Response in Trials of Negative Symptoms in Schizophrenia: A Critical Reassessment of the Evidence
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DOI: 10.1093/schbul/sbac061
Abstract: Abstract Background Summarizing evidence from clinical trials of patients with schizophrenia with predominant or prominent negative symptoms (NS), a prior meta-analysis reported a large placebo effect in negative symptoms (Cohen’s d = 2.909). Assuming that… read more here.
Keywords: negative symptoms; placebo response; effect; placebo ... See more keywords