High‐density lipoprotein‐like particle formation of Synuclein variants
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12543
Abstract: α‐Synuclein (α‐Syn) is an intrinsically disordered protein in solution whose fibrillar aggregates are the hallmark of Parkinson's disease (PD). Although the specific function of α‐Syn is still unclear, its high structural plasticity is key for… read more here.
Keywords: synuclein; high density; syn; density lipoprotein ... See more keywords
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha‐Synuclein and Enhance Therapy of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108435
Abstract: Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by enhancing the autophagy of microglia to phagocytose and degrade α‐syn via… read more here.
Keywords: parkinson disease; trpv1 channels; syn; alpha synuclein ... See more keywords
Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24468
Abstract: α‐Synuclein (α‐syn) is an abundant presynaptic protein that is the primary constituent of inclusions that define Lewy body diseases (LBDs). In these inclusions, α‐syn is phosphorylated at the serine‐129 residue. Antibodies directed to this phosphorylation… read more here.
Keywords: monoclonal antibodies; ps129 syn; syn; sensitivity specificity ... See more keywords
The good and bad of therapeutic strategies that directly target α‐synuclein
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2194
Abstract: Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α‐synuclein (α‐syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple… read more here.
Keywords: state; syn; good bad; pathology ... See more keywords
A tango for two: Dopamine and α‐synuclein synergy may explain nigrostriatal degeneration in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27248
Abstract: Dopamine (DA) and a-synuclein (a-syn) are 2 main factors linked to Parkinson’s disease. It is known that a-syn generates toxic oligomeric species that are stabilized by DA. Nonetheless, a-syn transgenic mice do not display dopaminergic… read more here.
Keywords: syn oligomers; dopamine synuclein; syn; mice ... See more keywords
Clues to Reshaping Anti‐α‐Synuclein Immunotherapy in Early Parkinson's Disease Patients
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DOI: 10.1002/mds.29294
Abstract: Alpha-synuclein (α-syn) aggregates are the hallmark pathological inclusions of Parkinson’s disease (PD). Even though its mechanisms of action are still unclear, multiple pathways of cellular dysfunction in models of α-syn toxicity have been described, and… read more here.
Keywords: immunotherapy; syn aggregates; parkinson disease; syn ... See more keywords
AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03013-x
Abstract: Parkinson’s disease (PD) is pathologically characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and alpha-synucleinopathy. We mimic the disease pathology with overexpression of either the human α-syn… read more here.
Keywords: syn; disease; syn e46k; substantia nigra ... See more keywords
Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0622-5
Abstract: In Parkinson’s disease and other Lewy body disorders, the propagation of pathology has been accredited to the spreading of extracellular α-synuclein (α-syn). Although the pathogenic mechanisms are not fully understood, cell-to-cell transfer of α-syn via… read more here.
Keywords: extracellular vesicles; synuclein; hemi venus; syn ... See more keywords
Unbiased Screens for Modifiers of Alpha-Synuclein Toxicity
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DOI: 10.1007/s11910-019-0925-z
Abstract: Purpose of ReviewWe provide an overview about unbiased screens to identify modifiers of alpha-synuclein (αSyn)-induced toxicity, present the models and the libraries that have been used for screening, and describe how hits from primary screens… read more here.
Keywords: syn; screens modifiers; toxicity; modifiers alpha ... See more keywords
α-Synuclein Promotes Maturation of Immature Juxtaglomerular Neurons in the Mouse Olfactory Bulb
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01814-3
Abstract: α-Synuclein (αSyn), the major constituent of Lewy bodies and Lewy neurites, is generally expressed in presynapses and is involved in synaptic function. However, we previously demonstrated that some neurons, including those in the olfactory bulb,… read more here.
Keywords: olfactory bulb; juxtaglomerular neurons; syn; mouse olfactory ... See more keywords
The small heat shock proteins αB-crystallin (HSPB5) and Hsp27 (HSPB1) inhibit the intracellular aggregation of α-synuclein
Sign Up to like & getrecommendations! Published in 2017 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-017-0785-x
Abstract: Protein homeostasis, or proteostasis, is the process of maintaining the conformational and functional integrity of the proteome. Proteostasis is preserved in the face of stress by a complex network of cellular machinery, including the small… read more here.
Keywords: aggregation; syn aggregation; small heat; hsp27 ... See more keywords