Clues to Reshaping Anti‐α‐Synuclein Immunotherapy in Early Parkinson's Disease Patients
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29294
Abstract: Alpha-synuclein (α-syn) aggregates are the hallmark pathological inclusions of Parkinson’s disease (PD). Even though its mechanisms of action are still unclear, multiple pathways of cellular dysfunction in models of α-syn toxicity have been described, and… read more here.
Keywords: immunotherapy; syn aggregates; parkinson disease; syn ... See more keywords
Chalcone Analogue as New Candidate for Selective Detection of α-Synuclein Pathology.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00441
Abstract: Deposition of α-synuclein (α-syn) aggregates is one of the neuropathological hallmarks of synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple-system atrophy. In vivo detection of α-syn aggregates with SPECT or PET may be… read more here.
Keywords: selective detection; pathology; chalcone; syn aggregates ... See more keywords
Structure-Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00279
Abstract: Synucleinopathies are characterized by the deposition of α-synuclein (α-syn) aggregates before the onset of clinical symptoms. Therefore, in vivo imaging of α-syn may contribute to early diagnosis of these diseases and has attracted much attention… read more here.
Keywords: relationships styrylquinoline; structure activity; syn aggregates; syn ... See more keywords
Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0182-z
Abstract: BackgroundPrionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whether this prionoid progression occurs via direct inter-neuronal transfer and, if… read more here.
Keywords: syn aggregates; syn; connectivity; pathology ... See more keywords
Alpha-Synuclein species in oral mucosa as potential biomarkers for multiple system atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1010064
Abstract: Background The definitive diagnosis of Multiple system atrophy (MSA) requires the evidence of abnormal deposition of α-Synuclein (α-Syn) through brain pathology which is unable to achieve in vivo. Deposition of α-Syn is not limited to… read more here.
Keywords: mucosal cells; oral mucosa; oral mucosal; syn aggregates ... See more keywords
Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00189
Abstract: Pathological aggregation of α-synuclein (α-syn) is a major component of Lewy bodies (LB), which play a central role in pathogenesis of Parkinson’s disease (PD). Differential expression of α-syn isoforms has been shown in PD. Isoform… read more here.
Keywords: injection syn; syn aggregates; syn; pathology ... See more keywords
Rifampicin quinone pretreatment improves neuronal survival by modulating microglia inflammation induced by α-synuclein
Sign Up to like & getrecommendations! Published in 2020 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.274336
Abstract: The World Health Organization has predicted that neurodegenerative diseases affecting the motor function will become the second most prevalent cause of death in the next 20 years. New therapies can result from three main sources:… read more here.
Keywords: pretreatment improves; rifampicin quinone; syn aggregates; quinone pretreatment ... See more keywords