The small heat shock proteins αB-crystallin (HSPB5) and Hsp27 (HSPB1) inhibit the intracellular aggregation of α-synuclein
Sign Up to like & getrecommendations! Published in 2017 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-017-0785-x
Abstract: Protein homeostasis, or proteostasis, is the process of maintaining the conformational and functional integrity of the proteome. Proteostasis is preserved in the face of stress by a complex network of cellular machinery, including the small… read more here.
Keywords: aggregation; syn aggregation; small heat; hsp27 ... See more keywords
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109617119
Abstract: Significance Converging evidence points to the build-up of phosphorylated α-synuclein (α-syn) at residue serine 129 (pS129) in Lewy body disease, suggesting its central role in the regulation of α-syn aggregation and neuronal degeneration. However, a… read more here.
Keywords: aggregation; toxicity; syn aggregation; serine 129 ... See more keywords
DNAJB6b is Downregulated in Synucleinopathies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-202512
Abstract: Background: α-synuclein (α-syn) aggregation contributes to the progression of multiple neurodegenerative diseases. We recently found that the isoform b of the co-chaperone DNAJB6 is a strong suppressor of α-syn aggregation in vivo and in vitro.… read more here.
Keywords: syn aggregation; disease; dnajb6b downregulated; dnajb6 ... See more keywords
Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson’s Disease
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DOI: 10.3390/ijms23031089
Abstract: Parkinson’s disease (PD) is the second-most common neurodegenerative disease in the world, affecting up to 10 million people. This disease mainly happens due to the loss of dopaminergic neurons accountable for memory and motor function.… read more here.
Keywords: parkinson disease; syn aggregation; fat protein; innate adaptive ... See more keywords
Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051467
Abstract: The search for disease-modifying agents targeted against Parkinson’s disease led us to rationally design a small array of six Anle138b-centered PROTACs, 7a,b, 8a,b and 9a,b, targeting αSynuclein (αSyn) aggregates for binding, polyubiquitination by the E3… read more here.
Keywords: aggregation; anle138b centered; centered protacs; syn aggregation ... See more keywords
Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
Sign Up to like & getrecommendations! Published in 2020 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.284993
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder belonging to a group of human pathologies known as synucleinopathies, which includes multiple system atrophy or dementia with Lewy bodies (Spillantini et al., 1998). These diseases share a… read more here.
Keywords: aggregation; syn aggregation; terminal domain; syn ... See more keywords