Polyphenols-Based Nanosheets of Propolis Modulate Cytotoxic Amyloid Fibril Assembly of α-Synuclein.
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DOI: 10.1021/acschemneuro.2c00465
Abstract: Natural compounds with anti-aggregation capacity are increasingly recognized as viable candidates against neurodegenerative diseases. Recently, the polyphenolic fraction of propolis (PFP), a complex bee product, has been shown to inhibit amyloid aggregation of a model… read more here.
Keywords: aggregation; based nanosheets; syn amyloid; pfp nanosheets ... See more keywords
Curcumin Interacts with α-Synuclein Condensates To Inhibit Amyloid Aggregation under Phase Separation
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DOI: 10.1021/acsomega.2c03534
Abstract: The amyloid aggregation of α-synuclein (α-Syn) is highly associated with Parkinson’s disease (PD). Discovering α-Syn amyloid inhibitors is one of the strategies for PD therapies. Recent studies suggested that α-Syn undergoes phase separation to accelerate… read more here.
Keywords: phase separation; separation; amyloid aggregation; syn amyloid ... See more keywords