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   Articles with "syn fibrils" as a keyword



Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein

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recommendations! Published in 2024 at "European Journal of Nuclear Medicine and Molecular Imaging"

DOI: 10.1007/s00259-024-06806-7

Abstract: There is an unmet need for compounds to detect fibrillar forms of alpha-synuclein (αSyn) and 4-repeat tau, which are critical in many neurodegenerative diseases. Here, we aim to develop an efficient surface plasmon resonance (SPR)-based… read more here.

Keywords: tau; syn fibrils; amyloid beta; binding sites ... See more keywords
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In situ architecture of neuronal α-Synuclein inclusions

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-22108-0

Abstract: The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to consist mainly of α-Syn fibrils, but recent reports pointed to intracellular membranes as the major… read more here.

Keywords: syn inclusions; synuclein; situ architecture; inclusions situ ... See more keywords

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-46538-8

Abstract: Parkinson’s disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease, and inactivating mutations to mitochondrial HTRA2… read more here.

Keywords: synuclein amyloid; disaggregates synuclein; syn fibrils; htra1 ... See more keywords

Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.

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recommendations! Published in 2025 at "Science"

DOI: 10.1126/science.adp3645

Abstract: Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptake of α-syn fibrils remain unclear. In this work, we identified FAM171A2… read more here.

Keywords: neuronal fam171a2; syn fibrils; fam171a2 mediates; parkinson disease ... See more keywords