A tango for two: Dopamine and α‐synuclein synergy may explain nigrostriatal degeneration in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27248
Abstract: Dopamine (DA) and a-synuclein (a-syn) are 2 main factors linked to Parkinson’s disease. It is known that a-syn generates toxic oligomeric species that are stabilized by DA. Nonetheless, a-syn transgenic mice do not display dopaminergic… read more here.
Keywords: syn oligomers; dopamine synuclein; syn; mice ... See more keywords
Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage
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DOI: 10.1212/wnl.0000000000201199
Abstract: Background and Objectives Robust biomarkers that can mirror Parkinson disease (PD) are of great significance. In this study, we present a novel approach to investigate disease-associated α-synuclein (αSyn) aggregates as biomarkers of PD clinical stage.… read more here.
Keywords: disease; parkinson disease; seeded syn; syn oligomers ... See more keywords