Beyond Just Connectivity — Neuronal Activity Drives α‐Synuclein Pathology
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders"
DOI: 10.1002/mds.28618
Abstract: A defining feature of Parkinson’s disease (PD) is the appearance of proteinaceous α-synuclein (αSYN)–laden inclusions — so-called Lewy pathology (LP) — in neurons. One of the most popular theories about the origins of LP in… read more here.
Keywords: movement; pathology; syn pathology; brain ... See more keywords
Neuropathology of α‐synuclein in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology"
DOI: 10.1111/neup.12812
Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive movement disability accompanied by non‐motor symptoms. The neuropathology hallmark of PD is the loss of dopaminergic neurons predominantly in the substantia nigra pars compacta and… read more here.
Keywords: synuclein parkinson; parkinson disease; syn pathology; neuropathology synuclein ... See more keywords
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0787-2
Abstract: The protein α-synuclein (αsyn) forms pathologic aggregates in a number of neurodegenerative diseases including Lewy body dementia (LBD) and Parkinson’s disease (PD). It is unclear why diseases such as LBD may develop widespread αsyn pathology,… read more here.
Keywords: syn; pathology; within amygdala; body dementia ... See more keywords
Relation of Enteric α-Synuclein to Gastrointestinal Dysfunction in Patients With Parkinson’s Disease and in Neurologically Intact Subjects
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurogastroenterology and Motility"
DOI: 10.5056/jnm17141
Abstract: Background/Aims α-Synucleinopathy in the brain is the neuropathological hallmark of Parkinson’s disease (PD). However, the functional impact of α-synucleinopathy in the enteric nervous system remains unknown. We aim to evaluate the association between gastrointestinal (GI)… read more here.
Keywords: syn pathology; intact subjects; pathology; parkinson disease ... See more keywords