High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
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DOI: 10.1186/s40478-021-01282-8
Abstract: Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD… read more here.
Keywords: seed; syn saa; synuclein seed; alpha synuclein ... See more keywords
A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson’s disease
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DOI: 10.1186/s40478-024-01873-1
Abstract: Seeding activities of disease-associated α-synuclein aggregates (αSynD), a hallmark of Parkinson’s disease (PD), are detectable by seed amplification assay (αSyn-SAA) and being developed as a diagnostic biomarker for PD. Sensitive and accurate αSyn-SAA for blood… read more here.
Keywords: syn saa; diagnosis; disease; sensitive accurate ... See more keywords
CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders
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DOI: 10.1212/wnl.0000000000209818
Abstract: Background and Objectives There is no disease-modifying treatment of corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), 2 disorders characterized by their striking phenotypic, and, in CBS, pathologic heterogeneity. Seed amplification assays (SAAs) could enable… read more here.
Keywords: syn saa; seed; saa positivity;
CSF α-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression.
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DOI: 10.1212/wnl.0000000000214346
Abstract: BACKGROUND AND OBJECTIVES α-Synuclein (αSyn) seed amplification assays (SAAs) accurately detect αSyn pathology in dementia with Lewy bodies (DLB). Alzheimer disease (AD) copathology occurs in ∼70% of patients with DLB at autopsy. The association of… read more here.
Keywords: year; seed; saa participants; syn saa ... See more keywords