Pre- and post-synaptic roles of action potential activity in synapse elimination revealed by using ectopic neuromuscular junction formation by a foreign nerve
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134835
Abstract: The formation of the neuromuscular junction (nmj) is based on molecular cascades initiated by neural agrin as well as electrical activity in the neuromuscular structures. This review focuses on the latter factor, emphasizing the multiplicity… read more here.
Keywords: pre post; formation; neuromuscular junction; activity ... See more keywords
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Sign Up to like & getrecommendations! Published in 2020 at "Nature neuroscience"
DOI: 10.1038/s41593-020-0672-0
Abstract: Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination remains unknown. Here, we show that… read more here.
Keywords: elimination; srpx2; synapse elimination; complement mediated ... See more keywords
Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-0963-8
Abstract: The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level… read more here.
Keywords: homeostatic presynaptic; presynaptic response; circuit; autaptic circuit ... See more keywords
Synaptic transmission is dispensable for selecting the winner input but is crucial for the subsequent events of synapse elimination.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2416797122
Abstract: Synaptic transmission has long been thought to regulate neuronal wiring during postnatal development, but this assumption remains largely untested. Selective strengthening of a single "winner" climbing fiber (CF) afferent to each Purkinje cell (PC) and… read more here.
Keywords: transmission; winner input; synapse elimination; synaptic transmission ... See more keywords
Emerging Roles for MFG‐E8 in Synapse Elimination
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.70009
Abstract: Synapse elimination is an essential process in the healthy nervous system and is dysregulated in many neuropathologies. Yet, the underlying molecular mechanisms and under what conditions they occur remain unclear. MFG‐E8 is a secreted glycoprotein… read more here.
Keywords: mfg synapse; roles mfg; synapse elimination; emerging roles ... See more keywords
Local and global predictors of synapse elimination during motor learning
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adk0540
Abstract: During learning, synaptic connections between excitatory neurons in the brain display considerable dynamism, with new connections being added and old connections eliminated. Synapse elimination offers an opportunity to understand the features of synapses that the… read more here.
Keywords: local global; synapse elimination; elimination; motor learning ... See more keywords
Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.23193
Abstract: In many parts of the nervous system, signals pass across multiple synaptic relays on their way to a destination, but little is known about how these relays form and the function they serve. To get… read more here.
Keywords: successive relays; motifs successive; elimination motifs; efferent pathway ... See more keywords