Pre- and post-synaptic roles of action potential activity in synapse elimination revealed by using ectopic neuromuscular junction formation by a foreign nerve
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134835
Abstract: The formation of the neuromuscular junction (nmj) is based on molecular cascades initiated by neural agrin as well as electrical activity in the neuromuscular structures. This review focuses on the latter factor, emphasizing the multiplicity… read more here.
Keywords: pre post; formation; neuromuscular junction; activity ... See more keywords
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Sign Up to like & getrecommendations! Published in 2020 at "Nature neuroscience"
DOI: 10.1038/s41593-020-0672-0
Abstract: Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination remains unknown. Here, we show that… read more here.
Keywords: elimination; srpx2; synapse elimination; complement mediated ... See more keywords
Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
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DOI: 10.1038/s42003-020-0963-8
Abstract: The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level… read more here.
Keywords: homeostatic presynaptic; presynaptic response; circuit; autaptic circuit ... See more keywords
Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice
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DOI: 10.7554/elife.23193
Abstract: In many parts of the nervous system, signals pass across multiple synaptic relays on their way to a destination, but little is known about how these relays form and the function they serve. To get… read more here.
Keywords: successive relays; motifs successive; elimination motifs; efferent pathway ... See more keywords