Nectin‐2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24958
Abstract: The medial habenula (MHb) receives afferents from the triangular septum and the medial septal complex, projects efferents to the interpeduncular nucleus (IPN) in the midbrain to regulate dopamine and serotonin levels, and is implicated in… read more here.
Keywords: nectin localized; catenin; synapse formation; localized cholinergic ... See more keywords
Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22638
Abstract: As the catalytic component of γ‐secretase, presenilin (PS) has long been studied in the context of Alzheimer’s disease through cleaving the amyloid precursor protein. PS/γ‐secretase, however, also cleaves a multitude of single‐pass transmembrane proteins that… read more here.
Keywords: receptor; presenilin; ephb2 receptor; synapse formation ... See more keywords
Intrinsic and extrinsic mechanisms of synapse formation and specificity in C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03109-1
Abstract: Precise neuronal wiring is critical for the function of the nervous system and is ultimately determined at the level of individual synapses. Neurons integrate various intrinsic and extrinsic cues to form synapses onto their correct… read more here.
Keywords: formation specificity; mechanisms synapse; intrinsic extrinsic; synapse formation ... See more keywords
Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-019-00347-y
Abstract: Neuroligins (NLs) are postsynaptic cell-adhesion proteins that play important roles in synapse formation and the excitatory-inhibitory balance. They have been associated with autism in both human genetic and animal model studies, and affect synaptic connections… read more here.
Keywords: subtype specific; pyramidal neurons; synapse formation; formation ... See more keywords
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell"
DOI: 10.1016/j.ccell.2017.02.001
Abstract: Summary The anti-FcRH5/CD3 T cell-dependent bispecific antibody (TDB) targets the B cell lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells. We demonstrate that TDBs trigger T cell receptor activation by inducing target clustering… read more here.
Keywords: synapse formation; anti fcrh5; cell; fcrh5 cd3 ... See more keywords
Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.015
Abstract: Normal brain functions depend on the balanced development of excitatory and inhibitory synapses. Our knowledge of the molecular mechanisms underlying inhibitory synapse formation is limited. Neuroligin-2 (NL2), a transmembrane protein at inhibitory postsynaptic sites, is… read more here.
Keywords: lhfpl4 garlh4; inhibitory synapse; synapse formation; nl2 binding ... See more keywords
Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.06.014
Abstract: Following axon pathfinding, growth cones transition from stochastic filopodial exploration to the formation of a limited number of synapses. How the interplay of filopodia and synapse assembly ensures robust connectivity in the brain has remained… read more here.
Keywords: seeding factors; synaptic seeding; synapse formation; formation ... See more keywords
Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2017.03.003
Abstract: Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in vertebrate and invertebrate nervous systems. Prominent family members are the neural cell adhesion molecules NCAM and L1, which were the first to be shown… read more here.
Keywords: immunoglobulin superfamily; adhesion molecules; neural cell; adhesion ... See more keywords
Neph2/Kirrel3 regulates sensory input, motor coordination, and home‐cage activity in rodents
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1111/gbb.12516
Abstract: Adhesion molecules of the immunoglobulin superfamily (IgSF) are essential for neuronal synapse development across evolution and control various aspects of synapse formation and maturation. Neph2, also known as Kirrel3, is an IgSF adhesion molecule implicated… read more here.
Keywords: home cage; motor; synapse formation; neph2 kirrel3 ... See more keywords
α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF‐β1 signaling in a Parkinson's disease model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14710
Abstract: Parkinson's disease (PD) is characterized by selective death of dopaminergic neurons in the substantia nigra, degeneration of the nigrostriatal pathway, increases in glutamatergic synapses in the striatum and aggregation of α‐synuclein. Evidence suggests that oligomeric… read more here.
Keywords: parkinson disease; tgf signaling; synapse formation; formation ... See more keywords
Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-alpha.
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.2210/pdb6kip/pdb
Abstract: Synapse formation is induced by transsynaptic interaction of neuronal cell-adhesion molecules termed synaptic organizers. Type IIa receptor protein tyrosine phosphatases (IIa RPTPs) function as presynaptic organizers. The cytoplasmic domain of IIa RPTPs consists of two… read more here.
Keywords: protein; type iia; synapse formation; interaction ... See more keywords