Presynaptic activity and protein turnover are correlated at the single-synapse level.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108841
Abstract: Synaptic transmission relies on the continual exocytosis and recycling of synaptic vesicles. Aged vesicle proteins are prevented from recycling and are eventually degraded. This implies that active synapses would lose vesicles and vesicle-associated proteins over… read more here.
Keywords: protein turnover; single synapse; turnover; synapse level ... See more keywords
Light-microscopy-based connectomic reconstruction of mammalian brain tissue
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DOI: 10.1038/s41586-025-08985-1
Abstract: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric… read more here.
Keywords: brain; microscopy based; synapse level; brain tissue ... See more keywords