TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.05.037
Abstract: Summary Microglia coordinate various functions in the central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, and clearing protein aggregates across the lifespan. Here we investigated whether increased… read more here.
Keywords: tdp depletion; microglia; synapse loss; pathology ... See more keywords
PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-05-0303
Abstract: Excess of Aβ42 peptide is considered a hallmark of the disease. Here we express the human Aβ42 peptide to assay the neuroprotective effects of PI3K in adult Drosophila melanogaster. The neuronal expression of the human… read more here.
Keywords: synapse loss; toxicity; pi3k; pi3k activation ... See more keywords
Flavonoids extracted from leaves of Diospyros kaki regulates RhoA activity to rescue synapse loss and reverse memory impairment in APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000989
Abstract: Synapse dysfunction is an early hallmark of Alzheimer’s disease (AD), and was considered to be closely related to memory loss. The molecular mechanisms that trigger synapse loss and dysfunction remain poorly understood. Increasing evidence shows… read more here.
Keywords: synapse loss; rho gtpases; ps1 mice; app ps1 ... See more keywords
Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.592607
Abstract: Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this review,… read more here.
Keywords: alzheimer disease; mouse models; synapse loss; loss ... See more keywords
Noise-Induced Hearing Loss in Gerbil: Round Window Assays of Synapse Loss
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.699978
Abstract: Previous work in animals with recovered hearing thresholds but permanent inner hair cell synapse loss after noise have suggested initial vulnerability of low spontaneous rate (SR) auditory nerve fibers (ANF). As these fibers have properties… read more here.
Keywords: round window; synapse loss; noise; loss ... See more keywords