Astrocyte‐mediated synapse remodeling in the pathological brain
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DOI: 10.1002/glia.23169
Abstract: Astrocytes, a major type of glia, reciprocally influence synaptic transmission and connectivity, forming the “tripartite synapses”. Astrocytic metabotropic glutamate receptor (mGluR)‐mediated Ca2+ waves and release of gliotransmitters or synaptogenic molecules mediate this neuron‐glia interaction in… read more here.
Keywords: synapse; pathological brain; mediated synapse; astrocyte mediated ... See more keywords
Developmental synapse remodeling in the cerebellum and visual thalamus
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DOI: 10.12688/f1000research.18903.1
Abstract: Functional neural circuits of mature animals are shaped during postnatal development by eliminating early-formed redundant synapses and strengthening of necessary connections. In the nervous system of newborn animals, redundant synapses are only transient features of… read more here.
Keywords: synapse remodeling; remodeling cerebellum; developmental synapse; visual thalamus ... See more keywords
Temporal Sequences of Synapse Disintegration Triggered by Afferent Axon Transection, Time-Lapse Imaging Study of Presynaptic and Postsynaptic Molecules
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DOI: 10.1523/eneuro.0459-18.2019
Abstract: Abstract Traumatic brain injury (TBI) is one of the major causes of death and disability. Multiple animal models have been developed to explore therapeutic targets for TBI. However, heterogeneity of pathophysiology obstructs discovery of therapeutic… read more here.
Keywords: afferent elimination; transection; synapse remodeling; temporal sequences ... See more keywords