Systematic Quantification of Synapses in Primary Neuronal Culture
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101542
Abstract: Summary Most neurological disorders display impaired synaptic connectivity. Hence, modulation of synapse formation may have therapeutic relevance. However, the high density and small size of synapses complicate their quantification. To improve synapse-oriented screens, we analyzed… read more here.
Keywords: synapse; systematic quantification; synapses primary; primary neuronal ... See more keywords
Spinal PKCĪ± inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons
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DOI: 10.1038/s41598-018-28512-9
Abstract: Upregulation of Ca2+-permeable AMPA receptors (CP-AMPARs) in dorsal horn (DH) neurons has been causally linked to persistent inflammatory pain. This upregulation, demonstrated for both synaptic and extrasynaptic AMPARs, depends on the protein kinase C alpha… read more here.
Keywords: spinal pkc; synapses primary; pkc inhibition; pain ... See more keywords