A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up or down scaling.
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DOI: 10.7554/elife.74277
Abstract: Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of posttranslational modifications in this process has not been systematically studied. Using deepscale quantitative analysis of the phosphoproteome in mouse… read more here.
Keywords: synaptic scaling; switch; shank3; phosphorylation ... See more keywords