Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.011
Abstract: Neuromodulators bind to pre- and postsynaptic G protein-coupled receptors (GPCRs), are able to quickly change intracellular cyclic AMP (cAMP) and Ca2+ levels, and are thought to play important roles in neuropsychiatric and neurodegenerative diseases. Here,… read more here.
Keywords: signaling bidirectionally; neuromodulator signaling; synapsin; synaptic vesicle ... See more keywords
Synapsin 1 promotes Aβ generation via BACE1 modulation
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DOI: 10.1371/journal.pone.0226368
Abstract: It has been revealed that β-amyloid (Aβ) is generated and released from the presynaptic terminals in activity-dependent manner. However, molecules modulating the presynaptic Aβ generation remain elusive. Here we test the hypothesis that Synapsin 1… read more here.
Keywords: modulation; synapsin; generation; generation via ... See more keywords
Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice
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DOI: 10.18632/oncotarget.24655
Abstract: Adult neurogenesis is emerging as an important player in brain functions and homeostasis, while impaired or altered adult neurogenesis has been associated with a number of neuropsychiatric diseases, such as depression and epilepsy. Here we… read more here.
Keywords: adult; synapsin; neurogenesis; syn ... See more keywords
The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality in Aphis gossypii
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169388
Abstract: Sublethal doses of insecticides have many impacts on pest control and agroecosystems. Insects that survive a sublethal dose of insecticide could adapt their physiological and behavioral functions and resist this environmental stress, which contributes to… read more here.
Keywords: aphis gossypii; thiamethoxam; synergistic effect; gene ... See more keywords