The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11507-z
Abstract: One of the most central questions about the repair of a double-strand DNA break (DSB) concerns how the two free DNA ends are brought together — a step called synapsis. Using single-molecule FRET (smFRET), we… read more here.
Keywords: two dna; dna; synapsis; dna ends ... See more keywords
Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
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DOI: 10.1093/nar/gkaa094
Abstract: Abstract During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite for ligation by XRCC4:Ligase IV (X4L4). This physical juxtaposition of DNA ends is called NHEJ synapsis. In… read more here.
Keywords: homologous dna; end joining; synapsis; dna end ... See more keywords
The telomere bouquet is a hub where meiotic double-strand breaks, synapsis, and stable homolog juxtaposition are coordinated in the zebrafish, Danio rerio
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007730
Abstract: Meiosis is a cellular program that generates haploid gametes for sexual reproduction. While chromosome events that contribute to reducing ploidy (homologous chromosome pairing, synapsis, and recombination) are well conserved, their execution varies across species and… read more here.
Keywords: telomere bouquet; synapsis; strand breaks; double strand ... See more keywords