Blocking TNFα‐driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23519
Abstract: Epilepsy is characterized by unpredictable recurrent seizures resulting from abnormal neuronal excitability. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability, but the underlying mechanism that… read more here.
Keywords: epilepsy; glutamate release; synaptic activity; activity ... See more keywords
Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-021-02411-2
Abstract: The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms… read more here.
Keywords: pentraxins biomarkers; neuronal pentraxins; synaptic activity; neurodegeneration ... See more keywords
nPKCε Mediates SNAP-25 Phosphorylation of Ser-187 in Basal Conditions and After Synaptic Activity at the Neuromuscular Junction
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1462-5
Abstract: Protein kinase C (PKC) and substrates like SNAP-25 regulate neurotransmission. At the neuromuscular junction (NMJ), PKC promotes neurotransmitter release during synaptic activity. Thirty minutes of muscle contraction enhances presynaptic PKC isoform levels, specifically cPKCβI and… read more here.
Keywords: snap phosphorylation; synaptic activity; ser 187; neuromuscular junction ... See more keywords
The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2426375122
Abstract: Significance Intellectual disability represents a core clinical manifestation of ZC4H2-associated rare disorder (ZARD), yet the underlying synaptic etiology remains elusive. In this study, with a conditional knockout mouse model depleting its pathogenic factor ZC4H2 in… read more here.
Keywords: rare disorder; zc4h2 associated; associated rare; zc4h2 ... See more keywords
Cannabinoids Shape Synaptic Activity and Adult Neurogenesis in the Zebrafish Pallium
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.70289
Abstract: The endocannabinoid system regulates neuronal activity and plasticity, but its role in non‐mammalian vertebrates remains poorly understood. In zebrafish (Danio rerio), the pallium processes cognitive functions such as memory, learning, and emotional behavior. This region… read more here.
Keywords: synaptic activity; adult neurogenesis; pallium; activity ... See more keywords
Novel Evoked Synaptic Activity Potentials (ESAPs) Elicited by Spinal Cord Stimulation
Sign Up to like & getrecommendations! Published in 2023 at "eNeuro"
DOI: 10.1523/eneuro.0429-22.2023
Abstract: Abstract Spinal cord stimulation (SCS) evokes fast epidural evoked compound action potential (ECAP) that represent activity of dorsal column axons, but not necessarily a spinal circuit response. Using a multimodal approach, we identified and characterized… read more here.
Keywords: evoked synaptic; synaptic activity; stimulation; spinal cord ... See more keywords
Comparative assessment of the effects of DREADDs and endogenously expressed GPCRs in hippocampal astrocytes on synaptic activity and memory
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1159756
Abstract: Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have proven themselves as one of the key in vivo techniques of modern neuroscience, allowing for unprecedented access to cellular manipulations in living animals. With respect to… read more here.
Keywords: hippocampal astrocytes; astrocytes synaptic; activity memory; synaptic activity ... See more keywords
5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050751
Abstract: The subtype 6 of the serotoninergic receptors (5-HT6Rs) is highly expressed in the hippocampus, and evidence indicates the beneficial effects of 5-HT6Rs blockade on short- and long-term memory in rodents. Nevertheless, the underlying functional mechanisms… read more here.
Keywords: inhibition; ht6 receptors; sex dependently; synaptic activity ... See more keywords
Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24020922
Abstract: Synaptic activity is the main energy-consuming process in the central nervous system. We are beginning to understand how energy is supplied and used during synaptic activity by neurons. However, the long-term metabolic adaptations associated with… read more here.
Keywords: mitochondrial iron; iron metabolism; synaptic activity; activity ... See more keywords