Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.02.001
Abstract: Aging is accompanied by increased neuroinflammation, synaptic dysfunction, and cognitive deficits both in rodents and humans, yet the onset and progression of these deficits throughout the life span remain unknown. These aging-related deficits affect the… read more here.
Keywords: cognitive deficits; advanced aged; age; treatment ... See more keywords
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awy354
Abstract: Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of ageing and neurodegeneration. Here we found that, in the late-stage familial Alzheimer's… read more here.
Keywords: alzheimer disease; synaptic cognitive; disease; fad mice ... See more keywords
5‐HT6R null mutatrion induces synaptic and cognitive defects
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13369
Abstract: Serotonin 6 receptor (5‐HT6R) is a promising target for a variety of human diseases, such as Alzheimer's disease (AD) and schizophrenia. However, the detailed mechanism underlying 5‐HT6R activity in the central nervous system (CNS) is… read more here.
Keywords: ht6r null; mutatrion induces; synaptic cognitive; ht6r ... See more keywords