Articles with "synaptic connectivity" as a keyword



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Using Fluorescent Markers to Estimate Synaptic Connectivity In Situ.

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Published in 2017 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-6688-2_20

Abstract: Labeling fixed brain tissue with fluorescent synaptic and cellular markers can help assess circuit connectivity. Despite the diffraction-limited resolution of light microscopy there are several approaches to identify synaptic contacts onto a cell-of-interest. Understanding which… read more here.

Keywords: estimate synaptic; synaptic connectivity; connectivity; using fluorescent ... See more keywords
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Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism.

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Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.05.006

Abstract: Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice. However, the functional effects of these mutations at cellular and circuit… read more here.

Keywords: prefrontal synaptic; autism; synaptic connectivity; reduced prefrontal ... See more keywords
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The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.

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Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109713

Abstract: Synaptic targeting with subcellular specificity is essential for neural circuit assembly. Developing neurons use mechanisms to curb promiscuous synaptic connections and to direct synapse formation to defined subcellular compartments. How this selectivity is achieved molecularly… read more here.

Keywords: protein; musashi; compartment; synaptic connectivity ... See more keywords
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Optimal Degrees of Synaptic Connectivity

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Published in 2017 at "Neuron"

DOI: 10.1016/j.neuron.2017.01.030

Abstract: Synaptic connectivity varies widely across neuronal types. Cerebellar granule cells receive five orders of magnitude fewer inputs than the Purkinje cells they innervate, and cerebellum-like circuits, including the insect mushroom body, also exhibit large divergences… read more here.

Keywords: degrees synaptic; optimal degrees; synaptic connectivity; connectivity ... See more keywords
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Automated synaptic connectivity inference for volume electron microscopy

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Published in 2017 at "Nature Methods"

DOI: 10.1038/nmeth.4206

Abstract: Teravoxel volume electron microscopy data sets from neural tissue can now be acquired in weeks, but data analysis requires years of manual labor. We developed the SyConn framework, which uses deep convolutional neural networks and… read more here.

Keywords: synaptic connectivity; electron microscopy; volume electron; microscopy ... See more keywords
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Cerebellar connectivity maps embody individual adaptive behavior in mice

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Published in 2022 at "Nature Communications"

DOI: 10.1038/s41467-022-27984-8

Abstract: The cerebellar cortex encodes sensorimotor adaptation during skilled locomotor behaviors, however the precise relationship between synaptic connectivity and behavior is unclear. We studied synaptic connectivity between granule cells (GCs) and Purkinje cells (PCs) in murine… read more here.

Keywords: connectivity; cerebellar connectivity; connectivity maps; synaptic connectivity ... See more keywords
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Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity

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Published in 2017 at "Cerebral Cortex"

DOI: 10.1093/cercor/bhx150

Abstract: Synaptic connectivity between neurons is naturally constrained by the anatomical overlap of neuronal arbors, the space on the axon available for synapses, and by physiological mechanisms that form synapses at a subset of potential synapse… read more here.

Keywords: diversity; synaptic connectivity; connectivity; morphological diversity ... See more keywords
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Quantitative analysis of rabies virus-based synaptic connectivity tracing

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Published in 2022 at "PLOS ONE"

DOI: 10.1101/2022.06.08.494952

Abstract: Monosynaptically restricted rabies viruses have been used for more than a decade for synaptic connectivity tracing. However, the verisimilitude of quantitative conclusions drawn from these experiments is largely unknown. The primary reason is the simple… read more here.

Keywords: connectivity; synaptic connectivity; starter cell; connectivity tracing ... See more keywords
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Observing Cell Assemblies From Spike Train Recordings Based on the Biological Basis of Synaptic Connectivity

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Published in 2022 at "IEEE Transactions on Biomedical Engineering"

DOI: 10.1109/tbme.2021.3123958

Abstract: Cell assemblies are difficult to observe because they consist of many neurons. We aimed to observe cell assemblies based on biological statistics, such as synaptic connectivity. We developed an estimation method to estimate the activity… read more here.

Keywords: based biological; cell assemblies; method; cell ... See more keywords
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Sexually differentiated microglia and CA1 hippocampal synaptic connectivity

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Published in 2023 at "Journal of Neuroendocrinology"

DOI: 10.1111/jne.13276

Abstract: Microglia have been shown to sculpt postnatal circuitry from birth up to adulthood due to their role in both synapse formation, synaptic pruning, and the elimination of weak, redundant synapses. Microglia are differentiated in a… read more here.

Keywords: synaptic connectivity; ca1; density; synapse ... See more keywords
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Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli

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Published in 2022 at "PLOS Computational Biology"

DOI: 10.1371/journal.pcbi.1010568

Abstract: Synaptic dysfunction is associated with several brain disorders, including Alzheimer’s disease, Parkinson’s disease (PD) and obsessive compulsive disorder (OCD). Utilizing synaptic plasticity, brain stimulation is capable of reshaping synaptic connectivity. This may pave the way… read more here.

Keywords: periodic multichannel; synaptic connectivity; burst stimuli; synaptic reshaping ... See more keywords