Using Fluorescent Markers to Estimate Synaptic Connectivity In Situ.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6688-2_20
Abstract: Labeling fixed brain tissue with fluorescent synaptic and cellular markers can help assess circuit connectivity. Despite the diffraction-limited resolution of light microscopy there are several approaches to identify synaptic contacts onto a cell-of-interest. Understanding which… read more here.
Keywords: estimate synaptic; synaptic connectivity; connectivity; using fluorescent ... See more keywords
Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.006
Abstract: Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice. However, the functional effects of these mutations at cellular and circuit… read more here.
Keywords: prefrontal synaptic; autism; synaptic connectivity; reduced prefrontal ... See more keywords
The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109713
Abstract: Synaptic targeting with subcellular specificity is essential for neural circuit assembly. Developing neurons use mechanisms to curb promiscuous synaptic connections and to direct synapse formation to defined subcellular compartments. How this selectivity is achieved molecularly… read more here.
Keywords: protein; musashi; compartment; synaptic connectivity ... See more keywords
Optimal Degrees of Synaptic Connectivity
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.01.030
Abstract: Synaptic connectivity varies widely across neuronal types. Cerebellar granule cells receive five orders of magnitude fewer inputs than the Purkinje cells they innervate, and cerebellum-like circuits, including the insect mushroom body, also exhibit large divergences… read more here.
Keywords: degrees synaptic; optimal degrees; synaptic connectivity; connectivity ... See more keywords
Automated synaptic connectivity inference for volume electron microscopy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Methods"
DOI: 10.1038/nmeth.4206
Abstract: Teravoxel volume electron microscopy data sets from neural tissue can now be acquired in weeks, but data analysis requires years of manual labor. We developed the SyConn framework, which uses deep convolutional neural networks and… read more here.
Keywords: synaptic connectivity; electron microscopy; volume electron; microscopy ... See more keywords
Cerebellar connectivity maps embody individual adaptive behavior in mice
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-27984-8
Abstract: The cerebellar cortex encodes sensorimotor adaptation during skilled locomotor behaviors, however the precise relationship between synaptic connectivity and behavior is unclear. We studied synaptic connectivity between granule cells (GCs) and Purkinje cells (PCs) in murine… read more here.
Keywords: connectivity; cerebellar connectivity; connectivity maps; synaptic connectivity ... See more keywords
Morphological Diversity Strongly Constrains Synaptic Connectivity and Plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhx150
Abstract: Synaptic connectivity between neurons is naturally constrained by the anatomical overlap of neuronal arbors, the space on the axon available for synapses, and by physiological mechanisms that form synapses at a subset of potential synapse… read more here.
Keywords: diversity; synaptic connectivity; connectivity; morphological diversity ... See more keywords
Quantitative analysis of rabies virus-based synaptic connectivity tracing
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1101/2022.06.08.494952
Abstract: Monosynaptically restricted rabies viruses have been used for more than a decade for synaptic connectivity tracing. However, the verisimilitude of quantitative conclusions drawn from these experiments is largely unknown. The primary reason is the simple… read more here.
Keywords: connectivity; synaptic connectivity; starter cell; connectivity tracing ... See more keywords
Observing Cell Assemblies From Spike Train Recordings Based on the Biological Basis of Synaptic Connectivity
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2021.3123958
Abstract: Cell assemblies are difficult to observe because they consist of many neurons. We aimed to observe cell assemblies based on biological statistics, such as synaptic connectivity. We developed an estimation method to estimate the activity… read more here.
Keywords: based biological; cell assemblies; method; cell ... See more keywords
Sexually differentiated microglia and CA1 hippocampal synaptic connectivity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13276
Abstract: Microglia have been shown to sculpt postnatal circuitry from birth up to adulthood due to their role in both synapse formation, synaptic pruning, and the elimination of weak, redundant synapses. Microglia are differentiated in a… read more here.
Keywords: synaptic connectivity; ca1; density; synapse ... See more keywords
Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010568
Abstract: Synaptic dysfunction is associated with several brain disorders, including Alzheimer’s disease, Parkinson’s disease (PD) and obsessive compulsive disorder (OCD). Utilizing synaptic plasticity, brain stimulation is capable of reshaping synaptic connectivity. This may pave the way… read more here.
Keywords: periodic multichannel; synaptic connectivity; burst stimuli; synaptic reshaping ... See more keywords