Distinct firing responses to synthetic synaptic currents in the adult murine reticular and relay thalamus
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neurophysiology"
DOI: 10.1152/jn.00052.2025
Abstract: Numerous cortical and subcortical inputs innervate the thalamus and robustly control thalamic activity. These synaptic inputs differ in shape and undergo dynamic changes throughout development and disease conditions. How the shape of postsynaptic currents regulates… read more here.
Keywords: nrt neurons; relay; synaptic currents; thalamus ... See more keywords
Quantitative prediction of intracellular dynamics and synaptic currents in a small neural circuit
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2025.1515194
Abstract: Fitting models to experimental intracellular data is challenging. While detailed conductance-based models are difficult to train, phenomenological statistical models often fail to capture the rich intrinsic dynamics of circuits such as central pattern generators (CPGs).… read more here.
Keywords: circuit; neural circuit; intracellular dynamics; data driven ... See more keywords
A Novel CNTNAP2 Mutation Results in Abnormal Neuronal E/I Balance
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.712773
Abstract: CNTNAP2 (coding for protein Caspr2), a member of the neurexin family, plays an important role in the balance of excitatory and inhibitory post-synaptic currents (E/I balance). Here, we describe a novel pathogenic missense mutation in… read more here.
Keywords: mutation; synaptic currents; cntnap2 r777g; balance ... See more keywords
Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00416
Abstract: Mammalian brainstem hypoglossal motoneurones (HMs) receive powerful synaptic glycinergic inputs and are involved in a variety of motor functions, including respiration, chewing, sucking, swallowing, and phonation. During the early postnatal development, subunit composition of chloride-permeable… read more here.
Keywords: changes inhibition; hypoglossal motoneurons; glycinergic synaptic; developmental changes ... See more keywords