Inhibition of glial D‐serine release rescues synaptic damage after brain injury
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24161
Abstract: Synaptic damage is one of the most prevalent pathophysiological responses to traumatic CNS injury and underlies much of the associated cognitive dysfunction; however, it is poorly understood. The D‐amino acid, D‐serine, serves as the primary… read more here.
Keywords: injury; synaptic damage; serine; brain ... See more keywords
Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-021-02411-2
Abstract: The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms… read more here.
Keywords: pentraxins biomarkers; neuronal pentraxins; synaptic activity; neurodegeneration ... See more keywords
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.05.021
Abstract: &NA; Prion diseases are a group of infectious neurodegenerative diseases characterized by multiple neuropathological hallmarks, including accumulation of PrPSc, synaptic damage, and neuronal death. We previously reported that the repressor element 1‐silencing transcription factor (REST),… read more here.
Keywords: wnt signaling; prion; lithium; rest ... See more keywords
Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy
Sign Up to like & getrecommendations! Published in 2024 at "Autophagy"
DOI: 10.1080/15548627.2024.2409613
Abstract: ABSTRACT Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired… read more here.
Keywords: traumatic brain; damage; brain injury; copper ... See more keywords
Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer’s disease: Mechanistic insights and potential therapies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2023.1099467
Abstract: Alzheimer’s disease (AD) is arguably the most common cause of dementia in the elderly and is marked by progressive synaptic degeneration, which in turn leads to cognitive decline. Studies in patients and in various AD… read more here.
Keywords: protein nitrosylation; synaptic damage; alzheimer disease; hyperexcitability ... See more keywords
Cuscutae Japonicae Semen Ameliorates Memory Dysfunction by Rescuing Synaptic Damage in Alzheimer’s Disease Models
Sign Up to like & getrecommendations! Published in 2019 at "Nutrients"
DOI: 10.3390/nu11112591
Abstract: Alzheimer’s disease (AD) is the most common type of dementia in the elderly. It is characterized by the accumulation of amyloid-beta (Aβ) and progressive cognitive impairment. To alleviate the symptoms of AD, functional foods and… read more here.
Keywords: alzheimer disease; dysfunction; japonicae semen; cuscutae japonicae ... See more keywords