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Published in 2022 at "Glia"
DOI: 10.1002/glia.24161
Abstract: Synaptic damage is one of the most prevalent pathophysiological responses to traumatic CNS injury and underlies much of the associated cognitive dysfunction; however, it is poorly understood. The D‐amino acid, D‐serine, serves as the primary…
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Keywords:
injury;
synaptic damage;
serine;
brain ... See more keywords
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Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-021-02411-2
Abstract: The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms…
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Keywords:
pentraxins biomarkers;
neuronal pentraxins;
synaptic activity;
neurodegeneration ... See more keywords
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Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.05.021
Abstract: &NA; Prion diseases are a group of infectious neurodegenerative diseases characterized by multiple neuropathological hallmarks, including accumulation of PrPSc, synaptic damage, and neuronal death. We previously reported that the repressor element 1‐silencing transcription factor (REST),…
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Keywords:
wnt signaling;
prion;
lithium;
rest ... See more keywords
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Published in 2023 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2023.1099467
Abstract: Alzheimer’s disease (AD) is arguably the most common cause of dementia in the elderly and is marked by progressive synaptic degeneration, which in turn leads to cognitive decline. Studies in patients and in various AD…
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Keywords:
protein nitrosylation;
synaptic damage;
alzheimer disease;
hyperexcitability ... See more keywords
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Published in 2019 at "Nutrients"
DOI: 10.3390/nu11112591
Abstract: Alzheimer’s disease (AD) is the most common type of dementia in the elderly. It is characterized by the accumulation of amyloid-beta (Aβ) and progressive cognitive impairment. To alleviate the symptoms of AD, functional foods and…
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Keywords:
alzheimer disease;
dysfunction;
japonicae semen;
cuscutae japonicae ... See more keywords