Trans‐Synaptic Degeneration Following Acute Optic Neuritis in Multiple Sclerosis
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DOI: 10.1002/ana.26529
Abstract: To explore longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis (AON) in people with multiple sclerosis (PwMS), to investigate the process of trans‐synaptic degeneration, and determine its clinical relevance. read more here.
Keywords: acute optic; following acute; trans synaptic; optic neuritis ... See more keywords
Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks
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DOI: 10.1038/s41598-018-29918-1
Abstract: Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain… read more here.
Keywords: dysregulated neurotransmission; brain; neuronal networks; trans synaptic ... See more keywords
HIV-associated synaptic degeneration
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DOI: 10.1186/s13041-017-0321-z
Abstract: Human immunodeficiency virus (HIV) infection induces neuronal injuries, with almost 50% of infected individuals developing HIV-associated neurocognitive disorders (HAND). Although highly activate antiretroviral therapy (HAART) has significantly reduced the incidence of severe dementia, the overall… read more here.
Keywords: associated synaptic; hiv; hand; synaptic degeneration ... See more keywords
Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum
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DOI: 10.2147/ndt.s224877
Abstract: Purpose Although emerging evidence has suggested that clusterin is involved in the pathogenesis of Alzheimer’s disease (AD), the association of clusterin with synaptic degeneration in living human is unclear. In the present study, we aimed… read more here.
Keywords: clusterin levels; synaptic degeneration; disease; association ... See more keywords