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   Articles with "synaptic degeneration" as a keyword



Trans‐Synaptic Degeneration Following Acute Optic Neuritis in Multiple Sclerosis

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recommendations! Published in 2022 at "Annals of Neurology"

DOI: 10.1002/ana.26529

Abstract: To explore longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis (AON) in people with multiple sclerosis (PwMS), to investigate the process of trans‐synaptic degeneration, and determine its clinical relevance. read more here.

Keywords: acute optic; following acute; trans synaptic; optic neuritis ... See more keywords

Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-29918-1

Abstract: Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain… read more here.

Keywords: dysregulated neurotransmission; brain; neuronal networks; trans synaptic ... See more keywords

HIV-associated synaptic degeneration

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recommendations! Published in 2017 at "Molecular Brain"

DOI: 10.1186/s13041-017-0321-z

Abstract: Human immunodeficiency virus (HIV) infection induces neuronal injuries, with almost 50% of infected individuals developing HIV-associated neurocognitive disorders (HAND). Although highly activate antiretroviral therapy (HAART) has significantly reduced the incidence of severe dementia, the overall… read more here.

Keywords: associated synaptic; hiv; hand; synaptic degeneration ... See more keywords

Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum

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recommendations! Published in 2020 at "Neuropsychiatric Disease and Treatment"

DOI: 10.2147/ndt.s224877

Abstract: Purpose Although emerging evidence has suggested that clusterin is involved in the pathogenesis of Alzheimer’s disease (AD), the association of clusterin with synaptic degeneration in living human is unclear. In the present study, we aimed… read more here.

Keywords: clusterin levels; synaptic degeneration; disease; association ... See more keywords

Resource-dependent heterosynaptic spike-timing-dependent plasticity in recurrent networks with and without synaptic degeneration

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recommendations! Published in 2025 at "Frontiers in Computational Neuroscience"

DOI: 10.3389/fncom.2025.1593837

Abstract: Many computational models that incorporate spike-timing-dependent plasticity (STDP) have shown the ability to learn from stimuli, supporting theories that STDP is a sufficient basis for learning and memory. However, to prevent runaway activity and potentiation,… read more here.

Keywords: resource dependent; recurrent networks; timing dependent; synaptic degeneration ... See more keywords