Longitudinal Synaptic Density PET with 11C‐UCB‐J 6 Months After Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26593
Abstract: The purpose of this study was to explore longitudinal changes in synaptic density after ischemic stroke in vivo with synaptic vesicle protein 2A (SV2A) positron emission tomography (PET). read more here.
Keywords: longitudinal synaptic; ischemic stroke; synaptic density; density pet ... See more keywords
Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.118167
Abstract: Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations. 11C-UCB-J PET maps synaptic density via synaptic… read more here.
Keywords: source networks; brain; synaptic density; 11c ucb ... See more keywords
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14122-0
Abstract: Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms… read more here.
Keywords: density marker; sv2a reduced; reduced schizophrenia; sv2a ... See more keywords
Abstract 31: CaMKII-alpha Ubiquitination Induced by Cerebral Ischemia-Reperfusion Injury Reversibly Inhibits Post-Ischemic CaMKII Activity at the Post-Synaptic Density
Sign Up to like & getrecommendations! Published in 2018 at "Stroke"
DOI: 10.1161/str.49.suppl_1.31
Abstract: Background: Brain calcium-calmodulin-dependent protein kinase II (CaMKII) is exclusively expressed in neurons, where it localizes to the post-synaptic density (PSD) to link calcium signals to chang... read more here.
Keywords: camkii; abstract camkii; post; synaptic density ... See more keywords
Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour
Sign Up to like & getrecommendations! Published in 2020 at "EJNMMI Research"
DOI: 10.1186/s13550-020-00721-2
Abstract: Background Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([ 11 C]UCB-J) provides the opportunity to visualize synaptic density changes in vivo,… read more here.
Keywords: pet; ucb pet; model; autoradiography ... See more keywords
PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.787404
Abstract: The development of novel PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A) allowed for the in vivo detection of synaptic density changes, which are correlated with the progression and severity of a variety of… read more here.
Keywords: sv2a pet; pet; synaptic density; pet imaging ... See more keywords
Imaging Synaptic Density: The Next Holy Grail of Neuroscience?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.796129
Abstract: The brain is the central and most complex organ in the nervous system, comprising billions of neurons that constantly communicate through trillions of connections called synapses. Despite being formed mainly during prenatal and early postnatal… read more here.
Keywords: imaging synaptic; synaptic density; density; density next ... See more keywords
Mathematical Modelling of Physiological Effects Caused by a Glycine Receptors Post-Synaptic Density Spatial Polymorphism
Sign Up to like & getrecommendations! Published in 2023 at "Mathematics"
DOI: 10.3390/math11112499
Abstract: Synaptic transmission is the main process providing cross-connecting activity among neurons in the central nervous system (CNS). In the present study, the 3D mathematical model of a neuronal bouton with a cluster localization of glycine… read more here.
Keywords: spatial polymorphism; post synaptic; glycine receptors; synaptic density ... See more keywords
The Rise of Synaptic Density PET Imaging
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25102303
Abstract: Many neurological disorders are related to synaptic loss or pathologies. Before the boom of positrons emission tomography (PET) imaging of synapses, synaptic quantification could only be achieved in vitro on brain samples after autopsy or… read more here.
Keywords: pet; rise synaptic; pet imaging; quantification ... See more keywords