Synaptic Density in Early Stages of Psychosis and Clinical High Risk.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2024.3608
Abstract: Importance Synaptic dysfunction is involved in schizophrenia pathophysiology. However, whether in vivo synaptic density is reduced in early stages of psychosis, including its high-risk states, remains unclear. Objective To investigate whether synaptic density (synaptic vesicle… read more here.
Keywords: early stages; synaptic density; high risk; stages psychosis ... See more keywords
Longitudinal Synaptic Density PET with 11C‐UCB‐J 6 Months After Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26593
Abstract: The purpose of this study was to explore longitudinal changes in synaptic density after ischemic stroke in vivo with synaptic vesicle protein 2A (SV2A) positron emission tomography (PET). read more here.
Keywords: longitudinal synaptic; ischemic stroke; synaptic density; density pet ... See more keywords
Synaptic Density Reductions in MSA: A Potential Biomarker Identified Through [18F]SynVesT‐1 PET Imaging
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Neurology"
DOI: 10.1002/ana.27179
Abstract: The objective of this study was to delineate synaptic density alterations in multiple system atrophy (MSA) and explore its potential role as a biomarker for MSA diagnosis and disease severity monitoring using [18F]SynVesT‐1 positron emission… read more here.
Keywords: synaptic density; pet; 18f synvest; density reductions ... See more keywords
Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.118167
Abstract: Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations. 11C-UCB-J PET maps synaptic density via synaptic… read more here.
Keywords: source networks; brain; synaptic density; 11c ucb ... See more keywords
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14122-0
Abstract: Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms… read more here.
Keywords: density marker; sv2a reduced; reduced schizophrenia; sv2a ... See more keywords
0257 Impact of Sleep Deprivation on Synaptic Density in Human Brains
Sign Up to like & getrecommendations! Published in 2025 at "SLEEP"
DOI: 10.1093/sleep/zsaf090.0257
Abstract: According to the synaptic homeostasis hypothesis, wakefulness will lead to an increase in synaptic strength. Several lines of evidence indicate in animals that markers of synaptic strength increase during wake and decline during sleep. Examples… read more here.
Keywords: synaptic strength; synaptic density; sleep deprivation; density ... See more keywords
Comparing GBA1‐Parkinson's disease and idiopathic Parkinson's disease: α‐Synuclein oligomers and synaptic density as biomarkers in the skin biopsy
Sign Up to like & getrecommendations! Published in 2024 at "Brain Pathology"
DOI: 10.1111/bpa.13284
Abstract: The main genetic risk factors for Parkinson's disease (PD) are presently represented by variants in GBA1 gene encoding for the β‐glucocerebrosidase (GCase). Searching for a peripheral biomarker that can be used for selecting and monitoring… read more here.
Keywords: synuclein oligomers; synaptic density; parkinson disease;
Abstract 31: CaMKII-alpha Ubiquitination Induced by Cerebral Ischemia-Reperfusion Injury Reversibly Inhibits Post-Ischemic CaMKII Activity at the Post-Synaptic Density
Sign Up to like & getrecommendations! Published in 2018 at "Stroke"
DOI: 10.1161/str.49.suppl_1.31
Abstract: Background: Brain calcium-calmodulin-dependent protein kinase II (CaMKII) is exclusively expressed in neurons, where it localizes to the post-synaptic density (PSD) to link calcium signals to chang... read more here.
Keywords: camkii; abstract camkii; post; synaptic density ... See more keywords
Sapap3 deletion causes dynamic synaptic density abnormalities: a longitudinal [11C]UCB-J PET study in a model of obsessive–compulsive disorder-like behaviour
Sign Up to like & getrecommendations! Published in 2020 at "EJNMMI Research"
DOI: 10.1186/s13550-020-00721-2
Abstract: Background Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([ 11 C]UCB-J) provides the opportunity to visualize synaptic density changes in vivo,… read more here.
Keywords: pet; ucb pet; model; autoradiography ... See more keywords
Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [11C]UCB-J PET
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.124.267419
Abstract: Visual Abstract Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios… read more here.
Keywords: tissue reference; simplified tissue; synaptic density; density ... See more keywords
Imaging Synaptic Density in Aging and Alzheimer Disease with [18F]SynVesT-1
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.124.269005
Abstract: Visual Abstract Synaptic density imaging with PET is a relatively new approach to monitoring synaptic injury in neurodegenerative diseases. However, there are remaining technical and clinical questions, including questions on reference region selection and on… read more here.
Keywords: alzheimer disease; whole brain; synaptic density; density ... See more keywords