Local biogenesis of autophagic vesicles in neuronal dendrites facilitates long-term synaptic depression
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2061757
Abstract: ABSTRACT Neurons are highly polarized and functionally compartmentalized cells. Under basal conditions, the biogenesis of autophagic vesicles (AVs) was previously shown to take place in the axon tip. As the sequestration of autophagic cargo occurs… read more here.
Keywords: long term; synaptic depression; biogenesis autophagic; autophagic vesicles ... See more keywords
miR-329– and miR-495–mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2022.03.08.483397
Abstract: In rat hippocampal neurons, miRNA-dependent regulation of the synaptic Prr7 protein is required for the homeostatic synaptic depression of excitatory synapses upstream of the CDK5-SPAR pathway. Homeostatic synaptic depression (HSD) in excitatory neurons is a… read more here.
Keywords: synaptic depression; hsd; rat hippocampal; regulation ... See more keywords
Aberrant Synaptic PTEN in Symptomatic Alzheimer’s Patients May Link Synaptic Depression to Network Failure
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.683290
Abstract: In Alzheimer’s disease (AD), Amyloid β (Aβ) impairs synaptic function by inhibiting long-term potentiation (LTP), and by facilitating long-term depression (LTD). There is now evidence from AD models that Aβ provokes this shift toward synaptic… read more here.
Keywords: depression; synaptic pten; aberrant synaptic; synaptic depression ... See more keywords