Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.02.011
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due to genetic, pathological and symptomatic overlap, ALS is… read more here.
Keywords: dysfunction; disease; c9orf72; als ftd ... See more keywords
T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105271
Abstract: Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH… read more here.
Keywords: entorhinal cortex; t1am; induced synaptic; effect ... See more keywords
SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac063
Abstract: Abstract Hereditary spastic paraplegia type 15 (HSP15) is a neurodegenerative condition caused by the inability to produce SPG15 protein, which leads to lysosomal swelling. However, the link between lysosomal aberrations and neuronal death is poorly… read more here.
Keywords: lysosomal abnormalities; spg15 protein; lipid metabolism; synaptic dysfunction ... See more keywords
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
Sign Up to like & getrecommendations! Published in 2018 at "Open Biology"
DOI: 10.1098/rsob.180138
Abstract: Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological synapse structure and function, and can be either the cause or the consequence in specific pathologies. Accumulating data in the field of neuropsychiatric… read more here.
Keywords: dysfunction; pluripotent stem; induced pluripotent; synaptic dysfunction ... See more keywords
Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13587
Abstract: Acrolein, an unsaturated aldehyde, is increased in the brain of Alzheimer's disease (AD) patients and identified as a potential inducer of sporadic AD. Synaptic dysfunction, as a typical pathological change occurring in the early stage… read more here.
Keywords: impairment; synaptic dysfunction; dysfunction; rhoa rock2 ... See more keywords
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13619
Abstract: Synaptic dysfunction is a key feature of Alzheimer's disease (AD). However, the molecular mechanisms underlying synaptic dysfunction remain unclear. Here, we show that synapsin Ⅰ, one of the most important synaptic proteins, is fragmented by… read more here.
Keywords: alzheimer disease; synaptic dysfunction; dysfunction; fragment ... See more keywords
TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0194-8
Abstract: BackgroundExcessive synaptic loss is thought to be one of the earliest events in Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown.… read more here.
Keywords: hyperactivity; synaptic dysfunction; trpa1 channels; ca2 hyperactivity ... See more keywords
Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00494-9
Abstract: Background Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behaviors and circuits of this newly… read more here.
Keywords: aldh1a1; mice; aldh1a1 neurons; synaptic dysfunction ... See more keywords
Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Genome Medicine"
DOI: 10.1186/s13073-018-0518-5
Abstract: Editorial summaryBreakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and… read more here.
Keywords: genetics; psychiatric disorders; synaptic dysfunction; complex psychiatric ... See more keywords
Pharmacological treatments for fragile X syndrome based on synaptic dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Current pharmaceutical design"
DOI: 10.2174/1381612825666191102165206
Abstract: BACKGROUND Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive impairment, including intellectual disability, autism, hyperactivity and epilepsy. METHODS This article reviews the literature pertaining to the role of synaptic dysfunction… read more here.
Keywords: fxs; pharmacological treatments; fragile syndrome; dysfunction ... See more keywords
From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00158
Abstract: The pathogenesis of Parkinson’s disease (PD) is thought to rely on a complex interaction between the patient’s genetic background and a variety of largely unknown environmental factors. In this scenario, the investigation of the genetic… read more here.
Keywords: synaptic dysfunction; dysfunction neuroprotective; disease; parkinson disease ... See more keywords