IFN-γ deficiency in the rostral ventrolateral medulla contributes to stress-induced hypertension by impairing microglial synaptic engulfment.
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DOI: 10.1097/hjh.0000000000003470
Abstract: BACKGROUND Dysfunctional neurons and microglia in the rostral ventrolateral medulla (RVLM) have been implicated in the pathogenesis of stress-induced hypertension (SIH). Functional perturbation of microglial synaptic engulfment can induce aberrant brain circuit activity. IFN-γ is… read more here.
Keywords: synaptic engulfment; engulfment; hypertension; microglial synaptic ... See more keywords