Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01146-6
Abstract: Reduced activity of the mediodorsal thalamus (MD) and abnormal functional connectivity of the MD with the prefrontal cortex (PFC) cause cognitive deficits in schizophrenia. However, the molecular basis of MD hypofunction in schizophrenia is not… read more here.
Keywords: schizophrenia associated; synaptic function; schizophrenia; mediodorsal thalamus ... See more keywords
A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42635-7
Abstract: MINT2/APBA2 is a synaptic adaptor protein involved in excitatory synaptic transmission. Several nonsynonymous coding variants in MINT2 have been identified in autism spectrum disorders (ASDs); however, these rare variants have not been examined functionally and… read more here.
Keywords: autism; trafficking synaptic; mint2 apba2; synaptic function ... See more keywords
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awab436
Abstract: Abstract Microtubules play fundamental roles in the maintenance of neuronal processes and in synaptic function and plasticity. While dynamic microtubules are mainly composed of tyrosinated tubulin, long-lived microtubules contain detyrosinated tubulin, suggesting that the tubulin… read more here.
Keywords: tubulin; alzheimer disease; synaptic function; tubulin tyrosination ... See more keywords
Impact of Synaptic Localization and Subunit Composition of Ionotropic Glutamate Receptors on Synaptic Function: Modeling and Simulation Studies
Sign Up to like & getrecommendations! Published in 2017 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2016.2561932
Abstract: Ionotropic NMDA and AMPA glutamate receptors (iGluRs) play important roles in synaptic function under physiological and pathological conditions. iGluRs sub-synaptic localization and subunit composition are dynamically regulated by activity-dependent insertion and internalization. However, understanding the… read more here.
Keywords: synaptic localization; synaptic function; impact synaptic; glutamate receptors ... See more keywords
Alterations in synaptic function and plasticity in Huntington disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14723
Abstract: Huntington disease (HD) is an inherited neurodegenerative disorder caused by an expansion of the CAG repeat region in the first exon of the huntingtin gene. Neurodegeneration, which begins in the striatum and then spreads to… read more here.
Keywords: huntington disease; synaptic function; plasticity; function plasticity ... See more keywords
Axonal transport: Driving synaptic function
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaw9997
Abstract: From trafficking to maintenance Neurons are remarkably polarized in that proteins made in the cytosol often need to travel many tens or hundreds of cell body lengths along axons to their sites of action in… read more here.
Keywords: delivery; transport; synaptic function; cell ... See more keywords
Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006815
Abstract: Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the functions of these genes are… read more here.
Keywords: drosophila insomniac; synaptic function; inc; cul3 ... See more keywords
Long-Lasting Input-Specific Experience-Dependent Changes of Hippocampus Synaptic Function Measured in the Anesthetized Rat
Sign Up to like & getrecommendations! Published in 2019 at "eNeuro"
DOI: 10.1523/eneuro.0506-18.2019
Abstract: Abstract How experience causes long-lasting changes in the brain is a central question in neuroscience. The common view is that synaptic function is altered by experience to change brain circuit functions that underlie conditioned behavior.… read more here.
Keywords: function; experience; long lasting; synaptic function ... See more keywords
Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.892196
Abstract: Endomembrane alkali cation (Na+, K+)/proton (H+) exchangers (eNHEs) are increasingly associated with neurological disorders. These eNHEs play integral roles in regulating the luminal pH, processing, and trafficking of cargo along the secretory (Golgi and post-Golgi… read more here.
Keywords: alkali cation; function; cation proton; endomembrane alkali ... See more keywords
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13010106
Abstract: Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors and affords robust… read more here.
Keywords: synaptic function; brain; caffeine intake;
Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14194137
Abstract: In recent decades, traditional eating habits have been replaced by a more globalized diet, rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary factors contribute to cognitive health impairment as… read more here.
Keywords: cognition; feeding brain; synaptic function; brain effect ... See more keywords