Coupling of synaptic inputs to local cortical activity differs among neurons and adapts after stimulus onset.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00398.2017
Abstract: Cortical activity contributes significantly to the high variability of sensory responses of interconnected pyramidal neurons, which has crucial implications for sensory coding. Yet, largely because of technical limitations of in vivo intracellular recordings, the coupling… read more here.
Keywords: inputs local; stimulus onset; synaptic inputs; local cortical ... See more keywords
Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009378
Abstract: Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output… read more here.
Keywords: activity; firing responses; synaptic inputs; intrinsic excitability ... See more keywords
Selectivity of Monaural Synaptic Inputs Underlying Binaural Auditory Information Integration in the Central Nucleus of Inferior Colliculus
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00303
Abstract: Neurons in the central nucleus of the inferior colliculus (ICC) receive ascending inputs from the ipsilateral and contralateral auditory pathway. However, the contributions of excitatory or inhibitory synaptic inputs evoked by ipsilateral and contralateral stimuli… read more here.
Keywords: ipsilateral contralateral; nucleus inferior; synaptic inputs; central nucleus ... See more keywords
Unraveling Functional Diversity of Cortical Synaptic Architecture Through the Lens of Population Coding
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.888214
Abstract: The synaptic inputs to single cortical neurons exhibit substantial diversity in their sensory-driven activity. What this diversity reflects is unclear, and appears counter-productive in generating selective somatic responses to specific stimuli. One possibility is that… read more here.
Keywords: synaptic inputs; two photon; diversity; population coding ... See more keywords
Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.945816
Abstract: Parkinson’s disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels of acetylcholine, disrupting the balance among these modulatory… read more here.
Keywords: synaptic inputs; dopamine depleted; striatal cins; activity ... See more keywords
Differential Serotonergic Modulation of Synaptic Inputs to the Olfactory Cortex
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031950
Abstract: Serotonin (5-hydroxytriptamine, 5-HT) is an important monoaminergic neuromodulator involved in a variety of physiological and pathological functions. It has been implicated in the regulation of sensory functions at various stages of multiple modalities, but its… read more here.
Keywords: synaptic inputs; modulation synaptic; olfactory cortex; inputs olfactory ... See more keywords