Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease
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DOI: 10.1002/adhm.202500941
Abstract: Tau hyperphosphorylation represents a critical pathological hallmark of Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by progressive cognitive decline. The ubiquitin‐specific proteases 14 (USP14) impairs proteasomal function and accelerates hyperphosphorylated Tau accumulation, making it… read more here.
Keywords: alzheimer disease; synaptic integrity; tau hyperphosphorylation; hyperphosphorylation ... See more keywords
Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35919-x
Abstract: Patients treated for cancer frequently experience chemobrain, characterized by impaired memory and reduced attention. These deficits often persist after treatment, and no preventive or curative interventions exist. In mice, we assessed the effect of cisplatin… read more here.
Keywords: synaptic integrity; cisplatin; attention; attention deficits ... See more keywords