7,8-Dihydroxycoumarin Alleviates Synaptic Loss by Activated PI3K-Akt-CREB-BDNF Signaling in Alzheimer’s Disease Model Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c02140
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is clinically characterized by the impairment of memory and cognition. Accumulation of β-amyloid (Aβ) in the brain is considered as a key process in the development… read more here.
Keywords: pi3k akt; alzheimer disease; creb bdnf; synaptic loss ... See more keywords
A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0659-y
Abstract: Older patients with severe physical trauma are at high risk of developing neuropsychiatric syndromes with global impairment of cognition, attention, and consciousness. We employed a thoracic trauma (TxT) mouse model and thoroughly analyzed age-dependent spatial… read more here.
Keywords: synaptic loss; trauma induced; crhr1 antagonist; induced delirium ... See more keywords
The synapse as a treatment avenue for Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01565-z
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder with devastating symptoms, including memory impairments and cognitive deficits. Hallmarks of AD pathology are amyloid-beta (Aβ) deposition forming neuritic plaques and neurofibrillary tangles (NFTs). For many years, AD… read more here.
Keywords: treatment; synapse; alzheimer disease; disease ... See more keywords