Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.01.012
Abstract: ABSTRACT Neuronal ageing is a complex physiological process, associated to metabolic and motor changes. In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor… read more here.
Keywords: old mice; synaptic mitochondria; active oxygen; aged mice ... See more keywords
Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.02.033
Abstract: Mitochondrial dysfunction has been shown to play a major role in neurodegenerative disorders such as Huntington's disease, Alzheimer's disease and Parkinson's disease. In these and other neurodegenerative disorders, disruption of synaptic connectivity and impaired neuronal… read more here.
Keywords: striatum cerebral; synaptic mitochondria; cerebral cortex; mitochondria striatum ... See more keywords
Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-90925-0
Abstract: Loss of synaptic activity correlates best with cognitive dysfunction in Alzheimer’s disease (AD). We have previously shown that mild inhibition of mitochondrial complex I with the small molecule tricyclic pyrone compound CP2 restores long-term potentiation… read more here.
Keywords: distribution; app ps1; synaptic mitochondria; small molecule ... See more keywords