Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03000-7
Abstract: Expression of the glutamate transporter GLT-1 in neurons has been shown to be important for synaptic mitochondrial function in the cerebral cortex. Here we determined whether neuronal GLT-1 plays a similar role in the hippocampus… read more here.
Keywords: glt; synglt; glt neurons; metabolism ... See more keywords
Tau talk – synaptic and mitochondrial proteins interact with Tau in human neurons
Sign Up to like & getrecommendations! Published in 2022 at "Trends in neurosciences"
DOI: 10.1016/j.tins.2022.02.004
Abstract: In a recent study, Tracy et al. observed that Tau interacts with mitochondrial and presynaptic vesicle proteins in human iPSC-derived neurons. Tau with mutations that cause neurodegeneration has decreased mitochondrial interactions. This elegant interactome mapping… read more here.
Keywords: tau talk; talk synaptic; mitochondrial proteins; proteins interact ... See more keywords
Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.852368
Abstract: Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and hyperphosphorylated forms of… read more here.
Keywords: synaptic mitochondrial; tau; tau accumulates; hyperphosphorylated human ... See more keywords