Genetic absence of ALOX5 protects from homocysteine‐induced memory impairment, tau phosphorylation and synaptic pathology
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx088
Abstract: &NA; Elevated level of homocysteine (Hcy) is considered a risk factor for neurodegenerative diseases, but the mechanisms remain to be established. Because high Hcy is associated with an up‐regulation of the ALOX5 gene product, the… read more here.
Keywords: hcy; synaptic pathology; homocysteine; memory impairment ... See more keywords
“Calcium bombs” as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.937974
Abstract: Excitotoxicity is thought to be an important factor in the onset and progression of amyotrophic lateral sclerosis (ALS). Evidence from human and animal studies also indicates that early signs of ALS include degeneration of motor… read more here.
Keywords: degeneration; neuromuscular junctions; calcium bombs; synaptic pathology ... See more keywords
Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040975
Abstract: Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic and glutamatergic synapses resulting in global dysconnectivity within and between brain networks. Impairments in inflammatory processes, mitochondrial functions, energy expenditure, and oxidative stress have… read more here.
Keywords: schizophrenia synaptic; antipsychotic treatment; synaptic pathology; pathology ... See more keywords
Synaptic pathology in multiple sclerosis: a role for Nogo-A signaling in astrocytes?
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.340407
Abstract: Multiple sclerosis (MS) is characterized as an inflammatory demyelinating disease that affects the central nervous system (CNS), leading to sensory, motor and cognitive impairments. Ultimately, axonal denudation culminates in axonal lesions and neurodegeneration. Inflammatory demyelinating… read more here.
Keywords: nogo signaling; role; synaptic pathology; pathology ... See more keywords