Lack of synaptic protein, calsyntenin‐2, impairs morphology of synaptic complexes in mice
Sign Up to like & getrecommendations! Published in 2019 at "Synapse"
DOI: 10.1002/syn.22132
Abstract: Calsyntenin‐2 (Clstn2) is the synaptic protein, which belongs to the superfamily of cadherins, playing an important role in learning and memory. We recently reported that Clstn2 knockout mice (Clstn2‐KO) have a deficit of GABAergic interneurons,… read more here.
Keywords: clstn2 mice; calsyntenin; synaptic protein; neurons clstn2 ... See more keywords
Maternal Immune Activation Causes Behavioral Impairments and Altered Cerebellar Cytokine and Synaptic Protein Expression
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.7
Abstract: Emerging epidemiology studies indicate that maternal immune activation (MIA) resulting from inflammatory stimuli such as viral or bacterial infections during pregnancy serves as a risk factor for multiple neurodevelopmental disorders including autism spectrum disorders and… read more here.
Keywords: immune activation; maternal immune; mia; expression ... See more keywords
O10.7. INVESTIGATING THE MECHANISMS UNDERLYING THE BENEFICIAL EFFECTS OF ESTROGENS IN SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby015.259
Abstract: Abstract Background Estrogens, in particular 17β-estradiol (estradiol) have repeatedly been shown to exert powerful influences over cognitive function, and in particular, on a range of cognitive behaviours associated with neurodevelopmental disorders. This includes depressive and… read more here.
Keywords: protein expression; ipsc neurons; expression; synaptic protein ... See more keywords
A synaptic protein defect associated with reflex seizure disorder
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000006720
Abstract: In this issue of Neurology®, Vlaskamp et al.1 report a multicenter, international (Australia, Italy, the Netherlands, Germany, the United States, and China), collaborative study analyzing the phenotypic spectrum associated with SYNGAP1 mutations with the aim… read more here.
Keywords: reflex seizure; synaptic protein; protein defect; defect associated ... See more keywords
Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.1008556
Abstract: Early-life adversity (ELA) can induce persistent neurological changes and increase the risk for developing affective or substance use disorders. Disruptions to the reward circuitry of the brain and pathways serving motivation and emotion have been… read more here.
Keywords: anxiety like; protein expression; synaptic protein; expression ... See more keywords