GPR56 S4 variant is required for microglia‐mediated synaptic pruning
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24293
Abstract: ADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not… read more here.
Keywords: synaptic pruning; microglia mediated; gpr56 variant; mediated synaptic ... See more keywords
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Neuroscience"
DOI: 10.1038/nrn.2017.110
Abstract: The final stage of brain development is associated with the generation and maturation of neuronal synapses. However, the same period is also associated with a peak in synapse elimination — a process known as synaptic… read more here.
Keywords: pruning; glial cell; cell dependent; synaptic pruning ... See more keywords
S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Psychiatry"
DOI: 10.1038/s41380-025-02949-7
Abstract: The impact of general anesthetics on neurodevelopment is highly controversial in terms of clinical and preclinical studies. Evidence mounted in recent years indicated development of social cognitions was more susceptible to general anesthesia in early… read more here.
Keywords: ketamine exposure; synaptic pruning; early postnatal; exposure ... See more keywords
Synaptic Pruning by Microglia: Lessons from Genetic Studies in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Developmental Neuroscience"
DOI: 10.1159/000541379
Abstract: Abstract Background: Neural circuits are subjected to refinement throughout life. The dynamic addition and elimination (pruning) of synapses are necessary for maturation of neural circuits and synaptic plasticity. Due to their phagocytic nature, microglia have… read more here.
Keywords: lessons genetic; pruning; synaptic pruning; pruning microglia ... See more keywords
Autophagy defects at weaning impair complement-dependent synaptic pruning and induce behavior deficits
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-024-03235-z
Abstract: Autophagy is crucial for synaptic plasticity and the architecture of dendritic spines. However, the role of autophagy in schizophrenia (SCZ) and the mechanisms through which it affects synaptic function remain unclear. In this study, we… read more here.
Keywords: autophagy defects; weaning impair; defects weaning; autophagy ... See more keywords
The Role of the Complement System in Synaptic Pruning after Stroke
Sign Up to like & getrecommendations! Published in 2024 at "Aging and Disease"
DOI: 10.14336/ad.2024.0373
Abstract: Stroke is a serious disease that can lead to local neurological dysfunction and cause great harm to the patient’s health due to blood cerebral circulation disorder. Synaptic pruning is critical for the normal development of… read more here.
Keywords: pruning stroke; complement; complement system; synaptic pruning ... See more keywords
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.599771
Abstract: Elements of the immune system particularly that of innate immunity, play important roles beyond their traditional tasks in host defense, including manifold roles in the nervous system. Complement-mediated synaptic pruning is essential in the developing… read more here.
Keywords: neuronal pentraxins; synaptic pruning; adult mice; c1q ... See more keywords