GPR56 S4 variant is required for microglia‐mediated synaptic pruning
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24293
Abstract: ADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not… read more here.
Keywords: synaptic pruning; microglia mediated; gpr56 variant; mediated synaptic ... See more keywords
Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Neuroscience"
DOI: 10.1038/nrn.2017.110
Abstract: The final stage of brain development is associated with the generation and maturation of neuronal synapses. However, the same period is also associated with a peak in synapse elimination — a process known as synaptic… read more here.
Keywords: pruning; glial cell; cell dependent; synaptic pruning ... See more keywords
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.599771
Abstract: Elements of the immune system particularly that of innate immunity, play important roles beyond their traditional tasks in host defense, including manifold roles in the nervous system. Complement-mediated synaptic pruning is essential in the developing… read more here.
Keywords: neuronal pentraxins; synaptic pruning; adult mice; c1q ... See more keywords