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Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix.

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0 Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.05.023

Abstract: Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, we mechanistically link these processes by uncovering a signaling pathway involving… read more here.

Keywords: depends signaling; extracellular matrix; serotonin receptors; synaptic remodeling ... See more keywords

Extracellular Matrix Muscle Arm Development Defective Protein Cooperates with the One Immunoglobulin Domain Protein To Suppress Precocious Synaptic Remodeling.

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0 Published in 2021 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.1c00194

Abstract: Synaptic remodeling plays important roles in health and neural disorders. Although previous studies revealed that several transcriptional programs control synaptic remodeling in the nematode Caenorhabditis elegans, the molecular mechanisms of the dorsal D-type (DD) synaptic… read more here.

Keywords: protein; muscle arm; extracellular matrix; precocious synaptic ... See more keywords

Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling

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0 Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2315958121

Abstract: Significance Neurons are endowed with the capacity to rapidly remodel their synaptic structure and strength in response to varying stimuli. This process, known as activity-induced synaptic remodeling, is crucial for the brain’s ability to transform… read more here.

Keywords: secretory autophagy; synaptic remodeling; activity induced; induced synaptic ... See more keywords

Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling

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0 Published in 2018 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2017.00440

Abstract: Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. The disease arises through loss of fragile X mental retardation protein (FMRP), which normally exhibits peak expression levels in early-use critical… read more here.

Keywords: protein; membrane trafficking; synaptic remodeling; fmrp ... See more keywords