Sleep, synaptic homeostasis and neuronal firing rates
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.03.016
Abstract: The synaptic homeostasis hypothesis (SHY) states that wake brings about a net overall increase in synaptic strength in many brain circuits that needs to be renormalized by sleep. I will review recent studies that were… read more here.
Keywords: firing rates; synaptic homeostasis; neuronal firing; firing ... See more keywords
Re-examination of the determinants of synaptic strength from the perspective of superresolution imaging
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2022.102540
Abstract: Synaptic strength is thought to be determined by the number of presynaptic release sites, release probability and postsynaptic response to quantal release. Changes in these parameters are directly relevant to synaptic plasticity. However, our understanding… read more here.
Keywords: synaptic strength; strength; determinants synaptic; strength perspective ... See more keywords
Intrinsic memory of temporal intervals in cerebellar Purkinje cells
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.107103
Abstract: The general consensus for learning and memory, including in the cerebellum, is that modification of synaptic strength via long-term potentiation (LTP) or long-term depression (LTD) are the primary mechanisms for the formation of memories. Recent… read more here.
Keywords: purkinje; purkinje cell; synaptic strength; cerebellar purkinje ... See more keywords
Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability
Sign Up to like & getrecommendations! Published in 2018 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0076-6
Abstract: The modification of synaptic strength produced by long-term potentiation (LTP) is widely thought to underlie memory storage. Indeed, given that hippocampal pyramidal neurons have >10,000 independently modifiable synapses, the potential for information storage by synaptic… read more here.
Keywords: memory formation; excitability; memory; synaptic strength ... See more keywords
A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207987119
Abstract: Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using non-negative tensor factorization (NTF) and conventional state modelling, we demonstrate that a kinetic scheme consisting of two… read more here.
Keywords: strength; two step; step; synaptic strength ... See more keywords
Paired Electrical Pulse Trains for Controlling Connectivity in Emotion-Related Brain Circuitry
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2020.3030714
Abstract: Neurostimulation therapies for psychiatric disorders often have limited clinical efficacy. The limited efficacy might arise from a mismatch between therapy and disease mechanisms. Mental disorders are believed to arise from communication breakdown in distributed brain… read more here.
Keywords: synaptic strength; connectivity; pulse trains; brain ... See more keywords
Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo4173
Abstract: The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters that are aligned with presynaptic release sites is essential for the high fidelity of synaptic transmission. However, the mechanisms controlling the nanoscale organization of neurotransmitter receptors… read more here.
Keywords: calyx held; synaptic transmission; synaptic strength; ampa receptors ... See more keywords
Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154361
Abstract: The striatum is a subcortical brain region responsible for the initiation and termination of voluntary movements. Striatal spiny projection neurons receive major excitatory synaptic input from neocortex and thalamus, and cyclic nucleotides have long been… read more here.
Keywords: cgmp sets; synaptic strength; cgmp; presynaptic cgmp ... See more keywords
Heterogeneous Responses to Changes in Inhibitory Synaptic Strength in Networks of Spiking Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.785207
Abstract: How does the dynamics of neurons in a network respond to changes in synaptic weights? Answer to this question would be important for a full understanding of synaptic plasticity. In this article, we report our… read more here.
Keywords: strength; network; synaptic strength; synaptic weights ... See more keywords
Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.81505
Abstract: Synapses contain a limited number of synaptic vesicles (SVs) that can be released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on… read more here.
Keywords: synaptic transmission; presynaptic rac1; synaptic strength; rac1 ... See more keywords