Hypothesis – buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission
Sign Up to like & getrecommendations! Published in 2017 at "Febs Letters"
DOI: 10.1002/1873-3468.12874
Abstract: Neural networks are optimized to detect temporal coincidence on the millisecond timescale. Here, we offer a synthetic hypothesis based on recent structural insights into SNAREs and the C2 domain proteins to explain how synaptic transmission… read more here.
Keywords: hypothesis buttressed; synaptic transmission; hypothesis; rings assemble ... See more keywords
Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801521
Abstract: Abstract Recreation of a muscle that can be controlled by the nervous system would provide a major breakthrough for treatments of injury and diseases. However, the underlying basis of how neuron–muscle interfaces are formed is… read more here.
Keywords: topography; aligned myotubes; topography regulates; synaptic transmission ... See more keywords
Microglia maintain the normal structure and function of the hippocampal astrocyte network
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24179
Abstract: Microglial control of activity‐dependent plasticity and synaptic remodeling in neuronal networks has been the subject of intense research in the past several years. Although microglia–neuron interactions have been extensively studied, less is known about how… read more here.
Keywords: structure function; astrocyte; function; synaptic transmission ... See more keywords
G protein‐coupled estrogen receptor‐1 enhances excitatory synaptic responses in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Hippocampus"
DOI: 10.1002/hipo.23383
Abstract: Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory… read more here.
Keywords: entorhinal cortex; cortex; coupled estrogen; synaptic transmission ... See more keywords
Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission.
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience bulletin"
DOI: 10.1007/s12264-020-00617-0
Abstract: Tweety-homolog 1 (Ttyh1) is expressed in neural tissue and has been implicated in the generation of several brain diseases. However, its functional significance in pain processing is not understood. By disrupting the gene encoding Ttyh1,… read more here.
Keywords: nociceptor excitability; tweety homolog; synaptic transmission; nociceptor ... See more keywords
Cephalosporin antibiotics are weak blockers of GABAa receptor-mediated synaptic transmission in rat brain slices.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.008
Abstract: Cephalosporins are beta-lactam antibiotics that are extensively used in medical practice and are reported to cause epileptic seizures in some patients. The primary cause of cephalosporin-induced convulsions is believed to be their ability to block… read more here.
Keywords: brain slices; ceftriaxone; gabaa receptor; synaptic transmission ... See more keywords
Double-edged GABAergic synaptic transmission in seizures: The importance of chloride plasticity
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.09.008
Abstract: GABAergic synaptic inhibition, which is a critical regulator of neuronal excitability, is closely involved in epilepsy. Interestingly, fast GABAergic transmission mediated by Cl- permeable GABAA receptors can bi-directionally exert both seizure-suppressing and seizure-promoting actions. Accumulating… read more here.
Keywords: synaptic transmission; gabaergic synaptic; chloride plasticity; pathology ... See more keywords
Acute hypoxic exposure and prolyl-hydroxylase inhibition improves synaptic transmission recovery time from a subsequent hypoxic insult in rat hippocampus
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.09.018
Abstract: In the CNS short episodes of acute hypoxia can result in a decrease in synaptic transmission which may be fully reversible upon re-oxygenation. Stabilization of hypoxia-inducible factor (HIF) by inhibition of prolyl hydroxylase domain (PHD)… read more here.
Keywords: recovery; inhibition; synaptic transmission; hypoxic ... See more keywords
A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons.
Sign Up to like & getrecommendations! Published in 2017 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.07.007
Abstract: The brainstem locus coeruleus (LC), the primary norepinephrinergic (NE) nucleus in the brain, has been implicated in the abuse of drugs such as opioids. However, whether and how the LC-NE system is involved in cocaine… read more here.
Keywords: transmission; transmission onto; synaptic transmission; locus coeruleus ... See more keywords
Vesicular Glutamate Transporter Expression Ensures High-Fidelity Synaptic Transmission at the Calyx of Held Synapses.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108040
Abstract: Recycling of synaptic vesicles (SVs) at presynaptic terminals is required for sustained neurotransmitter release. Although SV endocytosis is a rate-limiting step for synaptic transmission, it is unclear whether the rate of the subsequent SV refilling… read more here.
Keywords: calyx held; transmission; held synapses; synaptic transmission ... See more keywords
Synaptic adhesion molecules and excitatory synaptic transmission
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.03.005
Abstract: Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of… read more here.
Keywords: synaptic transmission; adhesion molecules; synaptic adhesion; excitatory synaptic ... See more keywords