Synaptic vesicle fusion is modulated through feedback inhibition by dopamine auto‐receptors
Sign Up to like & getrecommendations! Published in 2019 at "Synapse"
DOI: 10.1002/syn.22131
Abstract: Mechanisms of synaptic vesicular fusion and neurotransmitter clearance are highly controlled processes whose finely‐tuned regulation is critical for neural function. This modulation has been suggested to involve pre‐synaptic auto‐receptors; however, their underlying mechanisms of action… read more here.
Keywords: auto; vesicle fusion; auto receptors; fusion ... See more keywords
Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05149-3
Abstract: Purpose Synaptic abnormalities are associated with many brain disorders. Recently, we developed a novel synaptic vesicle glycoprotein 2A (SV2A) radiotracer [ 18 F]SynVesT-1 and demonstrated its excellent imaging and binding properties in nonhuman primates. The… read more here.
Keywords: reproducibility; test retest; test; synaptic vesicle ... See more keywords
Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02534-3
Abstract: Traumatic brain injury (TBI) can produce lasting cognitive, emotional, and somatic difficulties that can impact quality of life for patients living with an injury. Impaired hippocampal function and synaptic alterations have been implicated in contributing… read more here.
Keywords: traumatic brain; vesicle; synaptic vesicle; tbi ... See more keywords
Levetiracetam inhibits THP-1 monocyte chemotaxis and adhesion via the synaptic vesicle 2A.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.061
Abstract: Long-term therapy with older antiepileptic drugs (AEDs), but not levetiracetam (LEV), may increase the risk of atherosclerosis (AS), suggesting that LEV may have a potential anti-AS effect. The synaptic vesicle 2A (SV2A) is known to… read more here.
Keywords: synaptic vesicle; chemotaxis adhesion; thp monocyte; adhesion ... See more keywords
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.011
Abstract: Neuromodulators bind to pre- and postsynaptic G protein-coupled receptors (GPCRs), are able to quickly change intracellular cyclic AMP (cAMP) and Ca2+ levels, and are thought to play important roles in neuropsychiatric and neurodegenerative diseases. Here,… read more here.
Keywords: signaling bidirectionally; neuromodulator signaling; synapsin; synaptic vesicle ... See more keywords
Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.010
Abstract: Vesicle sharing between synaptic boutons is an important component of the recycling process that synapses employ to maintain vesicle pools. However, the mechanisms supporting and regulating vesicle transport during the inter-synaptic exchange remain poorly understood.… read more here.
Keywords: vesicle; exchange; inter synaptic; synaptic vesicle ... See more keywords
The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.045
Abstract: Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS… read more here.
Keywords: vesicle priming; adaptation sensory; sensory evoked; adaptation ... See more keywords
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110675
Abstract: α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in the vertebrate nervous system. α-synuclein functions in neurotransmitter release by binding to and clustering synaptic vesicles and chaperoning SNARE-complex assembly. Pathologically, aggregates originating from soluble pools… read more here.
Keywords: synaptic vesicle; binding synuclein; vesicle binding; synuclein ... See more keywords
A conditional GABAergic synaptic vesicle marker for Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2022.109540
Abstract: BACKGROUND Throughout the animal kingdom, GABA is the principal inhibitory neurotransmitter of the nervous system. It is essential for maintaining the homeostatic balance between excitation and inhibition required for the brain to operate normally. Identification… read more here.
Keywords: marker; conditional gabaergic; vesicle marker; neurotransmitter phenotyping ... See more keywords
Unique Lipid Chemistry of Synaptic Vesicle and Synaptosome Membrane Revealed Using Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00030
Abstract: Synaptic vesicles measuring 30-50 nm in diameter containing neurotransmitters either completely collapse at the presynaptic membrane or dock and transiently fuse at the base of specialized 15 nm cup-shaped lipoprotein structures called porosomes at the… read more here.
Keywords: synaptosome membrane; chemistry; vesicle synaptosome; synaptic vesicle ... See more keywords
Photoconversion of FM1-43 Reveals Differences in Synaptic Vesicle Recycling and Sensitivity to Pharmacological Disruption of Actin Dynamics in Individual Synapses.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00712
Abstract: The cycling of synaptic vesicles ensures that neurons can communicate adequately through their synapses on repeated occasions when activity is sustained, and several steps in this cycle are modulated by actin. The effects of pharmacological… read more here.
Keywords: vesicle; actin; vesicle recycling; photoconversion ... See more keywords