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   Articles with "synaptogenesis" as a keyword



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Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies

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recommendations! Published in 2017 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2016.06.016

Abstract: BACKGROUND Dysregulation of Ras-extracellular signal-related kinase (ERK) signaling gives rise to RASopathies, a class of neurodevelopmental syndromes associated with intellectual disability. Recently, much attention has been directed at models bearing mild forms of RASopathies whose… read more here.

Keywords: gamma aminobutyric; intellectual disability; synaptogenesis; model ... See more keywords

Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.01.102

Abstract: Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely… read more here.

Keywords: iqgap pes; synaptogenesis; glia promote; presynaptic formation ... See more keywords

The role of agrin, Lrp4 and MuSK during dendritic arborization and synaptogenesis in cultured embryonic CNS neurons.

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recommendations! Published in 2019 at "Developmental biology"

DOI: 10.1016/j.ydbio.2018.10.017

Abstract: The role of agrin, Lrp4 and MuSK, key organizers of neuromuscular synaptogenesis, in the developing CNS is only poorly understood. We investigated the role of these proteins in cultured mouse embryonic cortical neurons from wildtype… read more here.

Keywords: synaptogenesis; puncta; lrp4 musk; agrin lrp4 ... See more keywords

A transgenic zebrafish model for in vivo long-term imaging of retinotectal synaptogenesis

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-32409-y

Abstract: The retinotectal synapse in larval zebrafish, combined with live time-lapse imaging, provides an advantageous model for study of the development and remodelling of central synapses in vivo. In previous studies, these synapses were labelled by… read more here.

Keywords: synaptogenesis; zebrafish model; model vivo; stable lines ... See more keywords

Nano-scaffold containing functional motif of stromal cell-derived factor 1 enhances neural stem cell behavior and synaptogenesis in traumatic brain injury

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-85698-5

Abstract: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide, presenting a significant challenge due to the lack of effective therapies. Neural stem cells (NSCs) have shown promising potential in preclinical studies… read more here.

Keywords: scaffold containing; nano scaffold; brain; synaptogenesis ... See more keywords

The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0184238

Abstract: The number of synapses is a major determinant of behavior and many neural diseases exhibit deviations in that number. However, how signaling pathways control this number is still poorly understood. Using the Drosophila larval neuromuscular… read more here.

Keywords: equilibrium antagonistic; signaling pathways; synaptogenesis; number synapses ... See more keywords

The RNA-binding protein NANOS1 controls hippocampal synaptogenesis

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recommendations! Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0284589

Abstract: Proteins from the NANOS family are conserved translational repressors with a well-known role in gonad development in both vertebrates and invertebrates. In addition, Drosophila Nanos controls neuron maturation and function, and rodent Nanos1 affects cortical… read more here.

Keywords: binding protein; rna binding; synaptogenesis; hippocampal synaptogenesis ... See more keywords
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Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner

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recommendations! Published in 2021 at "eNeuro"

DOI: 10.1523/eneuro.0014-21.2021

Abstract: Abstract The regulation of synaptic connectivity in the brain is vital to proper functioning and development of the CNS. Formation of neural networks in the CNS has been shown to be heavily influenced by astrocytes,… read more here.

Keywords: synaptogenesis; response; astrocyte derived; thrombospondin induces ... See more keywords
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Astrocyte-Neuron Signaling in Synaptogenesis

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.680301

Abstract: Astrocytes are the key component of the central nervous system (CNS), serving as pivotal regulators of neuronal synapse formation and maturation through their ability to dynamically and bidirectionally communicate with synapses throughout life. In the… read more here.

Keywords: synaptogenesis; signaling synaptogenesis; astrocyte neuron; neuron ... See more keywords

Molecular mechanisms of synaptogenesis

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recommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"

DOI: 10.3389/fnsyn.2022.939793

Abstract: Synapses are the basic units for information processing and storage in the nervous system. It is only when the synaptic connection is established, that it becomes meaningful to discuss the structure and function of a… read more here.

Keywords: mechanisms synaptogenesis; synaptogenesis; molecular mechanisms; pathology ... See more keywords

Central Causation of Autism/ASDs via Excessive [Ca2+]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations

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recommendations! Published in 2024 at "Brain Sciences"

DOI: 10.3390/brainsci14050454

Abstract: The roles of perinatal development, intracellular calcium [Ca2+]i, and synaptogenesis disruption are not novel in the autism/ASD literature. The focus on six mechanisms controlling synaptogenesis, each regulated by [Ca2+]i, and each aberrant in ASDs is… read more here.

Keywords: six mechanisms; synaptogenesis; causation; asds ... See more keywords